著者

Chiharu Aizawa Masahiro Okabe Daisuke Takahashi Makoto Sagasaki Mao Watanabe Toshinari Fujimoto Yuuki Yoshioka Ai Katsuma Ai Kimura Daisuke Miyamoto Nana Sato Ken Okamoto Kimiyoshi Ichida Yoichi Miyazaki Takashi Yokoo

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

pp.0678-22, (Released:2023-02-08)

参考文献数

31

被引用文献数

1

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Exercise-induced acute kidney injury (EIAKI) is frequently complicated with renal hypouricemia (RHUC). In patients with RHUC, limiting anaerobic exercise can prevent EIAKI. However, it is challenging to reduce exercise intensity in athletes. We herein report a 16-year-old Japanese football player with familial RHUC with compound heterozygous mutations in urate transporter 1 (URAT1) who presented with recurrent EIAKI. As prophylaxis (hydration during exercise) could not prevent EIAKI, febuxostat was initiated. EIAKI was not observed for 16 months despite exercising intensively. Hence, non-purine-selective xanthine oxidoreductase inhibitors may decrease the incidence of EIAKI in athletes with RHUC.