- 著者
- Gaowa Wulantuya Xuhong Yin Minzhi Cao Shengchun Guo Chunlian Ding Lu Yuhua Luo Jianchang Hiroki Kawabata Shuji Ando Hongru Su Masahiko Shimada Naoya Takamoto Yuko Shimamura Shuichi Masuda Norio Ohashi
- 出版者
- National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee
- 雑誌
- Japanese Journal of Infectious Diseases (ISSN:13446304)
- 巻号頁・発行日
- pp.JJID.2017.450, (Released:2018-02-28)
- 参考文献数
- 15
- 被引用文献数
- 7
Anaplasma phagocytophilum is an obligate intracellular bacterium and causes febrile illness in humans and livestock. A 49-year-old woman was suffering from feverish symptom, fatigue, arthralgia, general body pain, and anorexia for 2 weeks. Later, she visited Bayan Nur Centers for Disease Control and Prevention Hospital in Inner Mongolia, China. Molecular-based diagnostic analysis of the patient’s blood revealed that A. phagocytophilum p44 DNA was positive, but Brucella omp31, spotted fever group Rickettsia gltA, Orientia tsutsugamushi 16S rDNA, and Ehrlichia p28 were negative. The amino acid sequences of 9 A. phagocytophilum p44 clones obtained from the patient shared 44-100% similarity among them and closely related to those of previously-identified p44 clones from canis familiaris (accession no. KJV64194) and from Ixodes persulcatus tick (no. BAN28309). Serological tests using the patient’s serum showed that IgM and IgG titers to A. phagocytophilum antigens were 160 and 20, respectively, determined by indirect immunofluorescence assay and the reaction to recombinant P44 proteins (rP44-1, rP44-18ES, and/or rP44-47) were confirmed by Western blot analysis. Thus, the results obtained in this study strongly suggests that the patient was infected with A. phagocytophilum. To our knowledge, this is a first case of human anaplasomosis infection in Inner Mongolia autonomous region.