著者
Satoshi Iwata Shinya Murata Shi Rong Han Akira Wakana Miyuki Sawata Yoshiyuki Tanaka
出版者
National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee
雑誌
Japanese Journal of Infectious Diseases (ISSN:13446304)
巻号頁・発行日
vol.70, no.4, pp.368-373, 2017 (Released:2017-07-24)
参考文献数
23
被引用文献数
3 4

A 9-valent human papillomavirus (HPV 6/11/16/18/31/33/45/52/58) virus-like particle vaccine (9vHPV) has been proven highly efficacious in preventing anogenital diseases related to HPV, in a pivotal phase III study for women aged 16-26 years. Here, we report the results of an open-label phase III study conducted to bridge the gap between the findings in women aged 16-26 years and Japanese girls aged 9-15 years. All subjects (n = 100) received a 3-dose regimen of 9vHPV vaccine on day 1 and at months 2 and 6. Anti-HPV serological assays were performed on day 1 and at months 7, 12, 24, and 30. At month 7 (4 weeks after the third dose), 100% of the subjects exhibited seroconversion for each type of HPV. Increases in geometric mean of the titers for anti-HPV 6/11/16/18/31/33/45/52/58 in the subjects were similar to those in Japanese women aged 16-26 years in a previous phase III study. Persistence of the anti-HPV response was observed for 2 years after administration of the third dose. In addition, administration of the 9vHPV vaccine was generally well-tolerated in Japanese girls.
著者
Hiroki Saito Hiroyuki Noda Shunji Takakura Kazuaki Jindai Rieko Takahashi McLellan Kazunari Asanuma
出版者
National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee
雑誌
Japanese Journal of Infectious Diseases (ISSN:13446304)
巻号頁・発行日
pp.JJID.2018.208, (Released:2018-08-31)
参考文献数
5

Antimicrobial resistance (AMR) is one of the top public health agendas in Japan. Since Japan published the national action plan (NAP) on AMR in 2016, the NAP implementation has been a major focus in Japan Ministry of Health, Labour and Welfare (MHLW). Japan MHLW recently published the 1st edition of “Manual of Antimicrobial Stewardship” (including English version), a narrative review with particular focus on outpatient setting of primary care and two common infectious disease conditions. This is one of very few occasions where MHLW proactively set a clinical guidance for health care delivery at facility level. Implementation of the manual will be further supported by the change in our social health insurance coverage.
著者
Hiroshi Yoshikura
出版者
National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee
雑誌
Japanese Journal of Infectious Diseases (ISSN:13446304)
巻号頁・発行日
pp.JJID.2018.228, (Released:2018-09-28)
参考文献数
4

The frequency of the ages of the HIV/AIDS deaths and that of the patients detected before or after the development of AIDS followed normal distribution. The median of HIV/AIDS deaths was 40-44 years in 1995-1998 and 50-54 years in 2014-2016, while the median of detection of the infection as “HIV” or as “AIDS” was constantly 25-29 years; it implied that the survival time of the HIV/AIDS patients became longer by 10 years in the past twenty odd years. The lengthening of the survival time could have been attributable to introduction of HIV/AIDS therapy, such as HAART. Importantly, however, during the same period, the life span of Japanese population was lengthened by near 10 years. Under the assumption that HIV/AIDS patients died 20 years after detection of the infection, the total number of the deaths was 1,446 in 1990-2016, which was close to the total number in Vital Statistics during the same period 1,532.
著者
Tetsuo Nakayama Shigeru Suga Kenji Okada Nobuhiko Okabe
出版者
National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee
雑誌
Japanese Journal of Infectious Diseases (ISSN:13446304)
巻号頁・発行日
pp.JJID.2018.314, (Released:2018-10-31)
参考文献数
23

A follow-up serological study was conducted involving 47 subjects who received four doses of diphtheria and tetanus toxoids combined with acellular pertussis vaccine (DTaP) together with Salk-type inactivated polio vaccine (DTaP-wIPV) until 6 years of age. All antibody levels declined more rapidly than expected within 3 years after the completion of the primary vaccination with 4th booster dose and titers persisted until 6 years of age. The positive rate of the IgG antibody against pertussis toxin (PT) was 31.9% (15/47) at 4 years of age, 41.0% (16/39) at 5 years of age, and 40.5% (15/37) at 6 years of age. A significant increase in the PT antibody was observed in 6 subjects, suggesting subclinical infection. Positive rates of antibodies against other targets did not decrease but titers of neutralizing antibodies against poliovirus type III decreased in only a few subjects. These data suggest the need for an additional preschool booster immunization using DTaP-wIPV.
著者
Hiroshi Yoshikura
出版者
National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee
雑誌
Japanese Journal of Infectious Diseases (ISSN:13446304)
巻号頁・発行日
pp.JJID.2018.183, (Released:2018-09-28)
参考文献数
16

In Japan, HIV infection is classified as “HIV” or “AIDS” depending upon whether the infection was detected before or after development of AIDS. For male homosexuals, in the plot of the number of “AIDS” versus the number of “HIV”, the plots fell on a straight line with a slope close to 1. When the number of “HIV” stopped increasing, that of “AIDS” stopped increasing. The number of “HIV” in one region or in one age group was correlated with that of other regions or that of other age groups, respectively. No such correlation was detected for male heterosexuals. Male homosexuals and females were detected more as “HIV” than male heterosexuals. Detection as “AIDS” increased with age in all the infection categories. Our analysis supported by others suggested that the higher rate of detection as “HIV” among male homosexuals and females than among male heterosexuals was attributable to higher risk of the receptive sexual intercourse, and the higher incidence of “AIDS” among elderlies to immunological senescence.
著者
Shinji Fukushima Hitoshi Kikuchi Mitsunobu Miyazu Atsuo Hamada Kazunobu Ouchi Hiroki Takagi Hanako Mihara Toru Sasaki Hayato Oka Valerie Bosch-Castells Philipp Oster
出版者
National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee
雑誌
Japanese Journal of Infectious Diseases (ISSN:13446304)
巻号頁・発行日
pp.JJID.2017.277, (Released:2018-06-29)
参考文献数
31

Meningococcal disease can cause significant disability and mortality. The quadrivalent meningococcal polysaccharide diphtheria toxoid conjugate vaccine (Men-ACWY-D) protects against invasive meningococcal disease caused by serogroups A, C, W, and Y. This phase III, open-label, single-arm, multicenter study evaluated the safety and immunogenicity of a single vaccine dose in healthy Japanese adults. The study enrolled 200 participants 2-55 years of age. Immunogenicity was assessed by quantifying seroprotection rates (the proportion of participants with antibody titers ≥1:128 against capsular polysaccharide from all 4 serogroups, measured 28 days after vaccination). Safety endpoints included occurrence, nature, time to onset, duration, intensity, relationship to vaccination, and outcome of solicited and unsolicited adverse events (AEs) and serious AEs (SAEs). Participants included 194 adults, 2 adolescents, and 4 children. Among adults, seroprotection rates for serogroups A, C, W, and Y were 91.2%, 80.2%, 89.1%, and 93.8%, respectively. Seroconversion rates (proportion of participants with pre-vaccination titers of <1:4 and a ≥4-fold rise from baseline) were 87.3%, 83.0%, 94.4%, and 96.4%, respectively. No immediate AEs or reactions, SAEs, or deaths were reported in any age group. Men-ACWY-D is well tolerated and immunogenic, eliciting antibodies against capsular polysaccharides from all 4 serogroups in Japanese adults.
著者
Yuichi Fukui Seigo Ohkawa Hisashi Inokuma
出版者
National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee
雑誌
Japanese Journal of Infectious Diseases (ISSN:13446304)
巻号頁・発行日
pp.JJID.2017.558, (Released:2018-04-27)
参考文献数
15

Anaplasma phagocytophilum DNA was detected from a dog with canine granulocytic anaplasmosis (CGA) in Japan. Phylogenetic analysis of the DNA using 16s rRNA, gltA, and groEL sequences revealed that the strain was nearly identical to A. phagocytophilum detected from Apodemus agrarius (black-striped field mouse) in China and Korea. This report is the first phylogenetic study on A. phagocytophilum from a CGA case in Japan.
著者
Gaowa Wulantuya Xuhong Yin Minzhi Cao Shengchun Guo Chunlian Ding Lu Yuhua Luo Jianchang Hiroki Kawabata Shuji Ando Hongru Su Masahiko Shimada Naoya Takamoto Yuko Shimamura Shuichi Masuda Norio Ohashi
出版者
National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee
雑誌
Japanese Journal of Infectious Diseases (ISSN:13446304)
巻号頁・発行日
pp.JJID.2017.450, (Released:2018-02-28)
参考文献数
15

Anaplasma phagocytophilum is an obligate intracellular bacterium and causes febrile illness in humans and livestock. A 49-year-old woman was suffering from feverish symptom, fatigue, arthralgia, general body pain, and anorexia for 2 weeks. Later, she visited Bayan Nur Centers for Disease Control and Prevention Hospital in Inner Mongolia, China. Molecular-based diagnostic analysis of the patient’s blood revealed that A. phagocytophilum p44 DNA was positive, but Brucella omp31, spotted fever group Rickettsia gltA, Orientia tsutsugamushi 16S rDNA, and Ehrlichia p28 were negative. The amino acid sequences of 9 A. phagocytophilum p44 clones obtained from the patient shared 44-100% similarity among them and closely related to those of previously-identified p44 clones from canis familiaris (accession no. KJV64194) and from Ixodes persulcatus tick (no. BAN28309). Serological tests using the patient’s serum showed that IgM and IgG titers to A. phagocytophilum antigens were 160 and 20, respectively, determined by indirect immunofluorescence assay and the reaction to recombinant P44 proteins (rP44-1, rP44-18ES, and/or rP44-47) were confirmed by Western blot analysis. Thus, the results obtained in this study strongly suggests that the patient was infected with A. phagocytophilum. To our knowledge, this is a first case of human anaplasomosis infection in Inner Mongolia autonomous region.
著者
Lattapon Suwanprinya Noppawan Phumala Morales Pimtip Sanvarinda Hamady Dieng Tamaki Okabayashi Ronald Enrique Morales Vargas
出版者
National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee
雑誌
Japanese Journal of Infectious Diseases (ISSN:13446304)
巻号頁・発行日
vol.70, no.4, pp.383-387, 2017 (Released:2017-07-24)
参考文献数
33

Encephalitis has been described worldwide as a severe complication in patients infected by dengue virus. Reactive oxygen species (ROS) production is a key mechanism involved in the neuronal damage caused by viral encephalitis. In the present study, the capability of dengue virus serotypes 2 (DENV2) and DENV4 to induce ROS production was investigated in a rat microglial cell line, HAPI cells. The cells were infected with DENV2 and DENV4 at a multiplicity of infection of 0.1 for a 2-h adsorption period. Japanese encephalitis virus (JEV) was used as the reference. DENV2- and DENV4-induced microglial activation and significantly increased ROS production corresponded to decreased cell viability. The activity of DENV4 was significantly higher than the activities of DENV2 and JEV at 48 and 72 h post infection. DENV4 partly induced ROS production via an iron-induced Fenton reaction, as demonstrated by the treatment with an iron chelator, deferiprone. Despite the induction of increased inducible nitric oxide synthase expression and nitric oxide (NO) production by JEV, DENV2, and DENV4 did not induce NO production, suggesting the activation of different pathways in response to infections by different viruses. In conclusion, DENV2 and DENV4 have the capability to induce ROS production and activate microglia, which have been reported as the key components of neuronal damage.
著者
Hiroki Ozawa Shigeru Tajima Eri Nakayama Kengo Kato Akifumi Yamashita Tsuyoshi Sekizuka Makoto Kuroda Shuzo Usuku
出版者
National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee
雑誌
Japanese Journal of Infectious Diseases (ISSN:13446304)
巻号頁・発行日
pp.JJID.2017.256, (Released:2017-12-26)
参考文献数
14

Zika virus (ZIKV) infection has been documented within Central and South America, Asia, and Africa. Here we report the isolation of virus from a patient infected with ZIKV returning to Japan from the Dominican Republic. The ZIKV strain was imaged by electron microscopy and its complete genome sequence was analyzed. Phylogenetic analysis and molecular characterization revealed that the strain was of the Asian lineage, and carried two unique mutations in its NS5 region. These mutations are characteristic of strains that originated in the Dominican Republic and the USA in 2016.
著者
Sukehiro Nayu Kida Nori Umezawa Masahiro Murakami Takayuki Arai Naoko Jinnai Tsunesada Inagaki Shunichi Tsuchiya Hidetoshi Maruyama Hiroshi Tsuda Yoshio
出版者
National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee
雑誌
Japanese Journal of Infectious Diseases (ISSN:13446304)
巻号頁・発行日
vol.66, no.3, pp.189-194, 2013
被引用文献数
18

The invasion of the yellow fever mosquito <i>Aedes aegypti</i> at Narita International Airport, Japan was detected for the first time. During the course of routine vector surveillance at Narita International Airport, 27 <i>Ae. aegypti</i> adults emerged from larvae and pupae collected from a single larvitrap placed near No. 88 spot at passenger terminal 2 on August 8, 2012. After the appearance of <i>Ae. aegypti</i> in the larvitrap, we defined a 400-m buffer zone and started an intensive vector survey using an additional 34 larvitraps and 15 CO<sub>2</sub> traps. International aircraft and passenger terminal 2 were also inspected, and one <i>Ae. aegypti</i> male was collected from the cargo space of an international aircraft from Darwin via Manila on August 28, 2012. Larvicide treatment with 1.5% fenitrothion was conducted in 64 catch basins and one ditch in the 400-m buffer zone. Twenty-four large water tanks were also treated at least once with 0.5% pyriproxyfen, an insect growth regulator. No <i>Ae. aegypti</i> eggs or adults were found during the 1-month intensive vector survey after finding larvae and pupae in the larvitrap. We concluded that <i>Ae. aegypti</i> had failed to establish a population at Narita International Airport.