著者

Narayanan VENKATESAN Gowri CHANDRAKASAN

出版者

SOCIETY FOR FREE RADICAL RESEARCH JAPAN

雑誌

Journal of Clinical Biochemistry and Nutrition (ISSN:09120009)

巻号頁・発行日

vol.15, no.2, pp.127-134, 1993 (Released:2010-02-25)

参考文献数

41

被引用文献数

1 1

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The present study evaluated the efficacy of taurine and niacin alone and in combination, in ameliorating the early lung injury found in paraquat-administered rats. At 24h after paraquat insult several biochemical indicators in bronchoalveolar lavage fluid were analyzed. Increases in total protein, albumin, lactate, lactate dehydrogenase, Nacetyl-β-D-glucosaminidase, alkaline phosphatase, acid phosphatase, and angiotensin-converting enzyme were evident in bronchoalveolar lavage fluid of paraquat-intoxicated rats. Serum and lung lipid peroxidation products were also found to be elevated in the paraquat rats. Pretreatment with taurine or niacin for 7 days before paraquat intoxication reduced the incidence of lung injury; however, far more dramatic protective effects was observed in combined treatment with taurine and niacin. A significant reduction in biochemical constituents in bronchoalveolar lavage fluid and lipid peroxidation occurred in paraquat groups pretreated with taurine and niacin. We conclude that taurine and niacin administration has a protective effect against paraquat-induced early lung injury through the beneficial effects of their antioxidant and membrane-stabilizing properties.