- 著者
- Atsushi Usami Takuya Sasaki Nobuhiro Satoh Takahiro Akiba Satoshi Yokoshima Tohru Fukuyama Kenzo Yamatsugu Motomu Kanai Masakatsu Shibasaki Norio Matsuki Yuji Ikegaya
- 出版者
- (公社)日本薬理学会
- 雑誌
- Journal of Pharmacological Sciences (ISSN:13478613)
- 巻号頁・発行日
- vol.106, no.4, pp.659-662, 2008 (Released:2008-04-19)
- 参考文献数
- 15
- 被引用文献数
- 24 33
Oseltamivir, a widely used anti-influenza drug, inhibits virus neuraminidase. A mammalian homologue of this enzyme is expressed in the brain, yet the effect of oseltamivir on central neurons is largely unknown. Patch-clamp recordings ex vivo revealed that oseltamivir enhanced spike synchronization between hippocampal CA3 pyramidal cells. Time-lapse multineuron calcium imaging revealed that oseltamivir and its active metabolite evoked synchronized population bursts that recruited virtually all neurons in the network. This unique, so-far-unknown, event was attenuated by muscarinic receptor antagonist. Thus, oseltamivir is a useful tool for investigating a new aspect of neural circuit operation.