著者
Ryosuke Kori Keigo Murakami Yoshitake Nishiyama Tatsuya Toma Satoshi Yokoshima
出版者
The Pharmaceutical Society of Japan
雑誌
Chemical and Pharmaceutical Bulletin (ISSN:00092363)
巻号頁・発行日
vol.69, no.3, pp.278-280, 2021-03-01 (Released:2021-03-01)
参考文献数
24
被引用文献数
1

We disclose our studies on a copper-mediated reaction of alkynes with trimethylsilyl azide to afford nitriles, and proposed a reaction mechanism, which involves an iodoalkyne and an iodotriazole as intermediates.
著者
Atsushi Usami Takuya Sasaki Nobuhiro Satoh Takahiro Akiba Satoshi Yokoshima Tohru Fukuyama Kenzo Yamatsugu Motomu Kanai Masakatsu Shibasaki Norio Matsuki Yuji Ikegaya
出版者
(公社)日本薬理学会
雑誌
Journal of Pharmacological Sciences (ISSN:13478613)
巻号頁・発行日
vol.106, no.4, pp.659-662, 2008 (Released:2008-04-19)
参考文献数
15
被引用文献数
24 33

Oseltamivir, a widely used anti-influenza drug, inhibits virus neuraminidase. A mammalian homologue of this enzyme is expressed in the brain, yet the effect of oseltamivir on central neurons is largely unknown. Patch-clamp recordings ex vivo revealed that oseltamivir enhanced spike synchronization between hippocampal CA3 pyramidal cells. Time-lapse multineuron calcium imaging revealed that oseltamivir and its active metabolite evoked synchronized population bursts that recruited virtually all neurons in the network. This unique, so-far-unknown, event was attenuated by muscarinic receptor antagonist. Thus, oseltamivir is a useful tool for investigating a new aspect of neural circuit operation.