- 著者
- Junichiro ASANO Peter LEE Vlad MYKHNENKO
- 出版者
- The City Planning Institute of Japan
- 雑誌
- Urban and Regional Planning Review (ISSN:21873399)
- 巻号頁・発行日
- vol.5, pp.135-152, 2018 (Released:2018-12-21)
- 参考文献数
- 16
- 被引用文献数
- 2
Natural Disaster gives serious impact and damage to city structure not only by disaster itself but also by reconstruction project after this. In depopulation era like in Japan, it is necessary to consider reconstruction plan in urban shrinking context with future low demand. This study clarifies reconstruction situation after eruption disaster of Mt. Unzen and recent urban shrinking in Shimabara City in order to consider urban resilience lesson. This study takes empirical method with official planning documents research, interview to key persons, questionnaire survey, and so on, and clarifies as follows. Since the residents' intention and consciousness for reconstruction needs to be intensified in reconstruction from a large-scale disaster, the reconstruction plans tend to be expansion-oriented. However, it is an illusion that temporary reconstruction projects bring the recovery of population in local cities in Japan. As the case from Shimabara, the followings can be pointed out as the concrete necessity. First, it is necessary to prepare a plan for housing developments for survivors which considers the future maturation of the development areas (especially the selection of their locations and the necessity of public transportation) and to carry out land readjustment considering demand for land after completion. In addition, as symbolically indicated by the abolishment of a Shimabara Railroad line after its reconstruction, it is necessary to prepare reconstruction plans of public transportation based on a strict demand forecast. Furthermore, reconstruction projects should be incorporated into city planning considering its sustainability.
- 著者
- Hitomi ODA Akihiro MORI Peter LEE Kaori SAEKI Toshiro ARAI Toshinori SAKO
- 出版者
- 公益社団法人 日本獣医学会
- 雑誌
- Journal of Veterinary Medical Science (ISSN:09167250)
- 巻号頁・発行日
- pp.13-0590, (Released:2014-06-16)
- 被引用文献数
- 2
Sitagliptin is a dipeptidyl peptidase-4 inhibitor aimed at treating Type 2 diabetes mellitus (T2DM) and T1DM, by increasing blood levels of Glucagon-like peptide 1 (GLP-1) and insulin. The objective of this preliminary study is to characterize Sitagliptin’s ability for glycemic control, in healthy dogs under an oral glucose tolerance test (OGTT) environment. Overall, Sitagliptin did not result in any significant changes to temporal glucose and insulin concentrations. However, a ~55% increase in median total GLP-1 AUC0–120min was observed, as compared to baseline control in healthy dogs (n=5), thus indicating a similar mode of action of Sitagliptin between healthy dogs and humans. Future studies to validate the use of Sitagliptin with dogs suffering from insulin independent diabetes are warranted.
- 著者
- Kana MIMURA Akihiro MORI Peter LEE Kaori UEDA Hitomi ODA Kaori SAEKI Toshiro ARAI Toshiro SAKO
- 出版者
- 公益社団法人 日本獣医学会
- 雑誌
- Journal of Veterinary Medical Science (ISSN:09167250)
- 巻号頁・発行日
- pp.12-0310, (Released:2013-03-01)
- 被引用文献数
- 1 5
Diet therapy is an important treatment component available for obese cats. In this study, the impact of four commercially available prescription diet regimens [1 for general use and 3 aimed at treating obesity and diabetes mellitus (DM)] on short-term post-prandial serum glucose, insulin, triglyceride and non-esterified fatty acid (NEFA) concentrations was investigated with five obese cats. The diet regimens used were as follows: C/D dry (general use: moderate protein, moderate fat, high carbohydrate and low fiber); M/D dry (DM: high protein, high fat, low carbohydrate and high fiber); W/D dry (DM: high protein, low fat, high carbohydrate and high fiber); and Diabetic dry (DM: high protein, low fat, low carbohydrate and high fiber). A significant reduction (10–13%) in postprandial glucose (area under the curve; AUC) was observed with the M/D and Diabetic diets, which both contained lower concentrations of carbohydrates than the C/D diet. An accompanying significant reduction (30–36%) in postprandial insulin AUC was also observed with the three DM diets, which all had higher amounts of fiber, as compared with the C/D diet. Lastly, a significant increase (32–65%) in postprandial NEFA AUC was observed with the M/D and Diabetic diets as compared with the C/D diet. Therefore, dietary amounts of carbohydrates and fiber, as opposed to protein content or dietary fat, appear to have a very significant impact on post-prandial glycemia and subsequent insulin requirement levels in obese cats. In addition, dietary amounts of carbohydrate may also impact lipid metabolism in obese cats.
- 著者
- Hiroko FUKUTA Akihiro MORI Nazarbek URUMUHAN Peter LEE Hitomi ODA Kaori SAEKI Miyuki KURISHIMA Satoshi NOZAWA Hisashi MIZUTANI Suguru MISHINA Toshiro ARAI Toshinori SAKO
- 出版者
- 公益社団法人 日本獣医学会
- 雑誌
- Journal of Veterinary Medical Science (ISSN:09167250)
- 巻号頁・発行日
- pp.12-0041, (Released:2012-07-06)
- 被引用文献数
- 2 7
Euglycemic-hyperinsulinemic glucose clamp (EHGC) method is a gold standard for assessing insulin resistance in humans. However, this method has yet to be commonly used with dogs, due to the requirement of frequent blood sampling for glucose measurement and adjusting glucose infusion rate (GIR). The purpose of this study was to evaluate insulin resistance, induced either by Cushing Syndrome (CS) or diestrus in dogs, as determined by GIR by EHGC, using an artificial pancreas apparatus. Twenty animals were used in this study with ten (7 females and 3 males) serving as healthy controls, four (3 females, 1 male) diagnosed with CS, and six (all females) undergoing diestrus. A higher GIR value indicates increased insulin sensitivity and lower insulin resistance. GIR of healthy control animals was determined to be within a reference range of [10.6–21.3] with a median of 15.2 mg/kg/min. In comparison, the CS group had a median of 5.4 mg/kg/min; whereas the diestrus group exhibited a median of 8.9 mg/kg/min. Insulin resistant animals suffering from CS and undergoing diestrus demonstrated reductions of 65 and 40% in GIR, respectively; thus indicating differences in degree of insulin insensitivity can be discerned using the EHGC method.