- 著者
- Ching Yu Lin Mark R. Viant Ronald S. Tjeerdema
- 出版者
- 日本農薬学会
- 雑誌
- Journal of Pesticide Science (ISSN:1348589X)
- 巻号頁・発行日
- vol.31, no.3, pp.245-251, 2006 (Released:2006-08-24)
- 参考文献数
- 67
- 被引用文献数
- 62 156
Environmental metabolomics is an emerging approach for examining metabolic fingerprints, or profiles, in biological systems exposed to environmental stress. In conjunction with other “omics” techniques, such as genomics, transcriptomics, and proteomics, it has been used to study the biochemical impacts of xenobiotics and disease. The approach analyzes changes in the concentrations of metabolites, which are the precursors and products of enzymatic activity, and then attempts to associate these changes with biological function and/or regulation. Environmental scientists have recently applied such techniques to suggest biomarkers for the risk assessment of chemicals and for diagnosing diseases in wild animals. Furthermore, this approach can in principle allow scientists to better understand the underlying mechanisms of action of toxic compounds in the environment. In this review the methodologies used in metabolomics are briefly discussed along with several examples from the environmental sciences, including biomarker development and risk assessment of toxicant exposure, metabolic responses to environmental stressors, and disease diagnosis and monitoring.
- 著者
- Amrith S. Gunasekara Tresca Truong Kean S. Goh Frank Spurlock Ronald S. Tjeerdema
- 出版者
- Pesticide Science Society of Japan
- 雑誌
- Journal of Pesticide Science (ISSN:1348589X)
- 巻号頁・発行日
- vol.32, no.3, pp.189-199, 2007 (Released:2007-08-27)
- 参考文献数
- 47
- 被引用文献数
- 184 268
Fipronil is a relatively new insecticide that controls a broad spectrum of insects at low field application rates. It is a “new generation” insecticide because its mode of action, interference with the normal function of γ-aminobutyric acid (GABA)-gated channels, differs from the classical insecticides, such as organophosphates and carbamates, to which some insects have developed resistance. Fipronil is extensively used throughout the world and numerous studies have evaluated its toxicity and environmental fate. However, a concise review summarizing and combining the recent scientific findings available in the scientific literature is lacking even though the pesticide has been found to be highly toxic to some aquatic organisms. Thus, this document evaluates, summarizes, and combines important toxicological and environmental fate information from recent scientific articles and other literature to produce a detailed review of fipronil.