- 著者
- Sayaka Mizuno Ryo Miyata Muhamad Sahlan Shigenori Kumazawa
- 出版者
- Japanese Society for Food Science and Technology
- 雑誌
- Food Science and Technology Research (ISSN:13446606)
- 巻号頁・発行日
- pp.FSTR-D-23-00006, (Released:2023-03-10)
Indonesian Calophyllum inophyllum resin and its main component, calophylloidic acid A (1), have potent antibacterial activity against foodborne pathogens such as Staphylococcus aureus and Escherichia coli. However, their low water solubility makes their practical use difficult. Here, we investigated the formation of inclusion complexes of C. inophyllum resin and 1 with cyclodextrins (CDs). The inclusion complexes of C. inophyllum resin or 1 with CDs exhibited enhanced water solubility and antibacterial activity against S. aureus and E. coli compared to those of uncomplexed C. inophyllum resin or 1. Among the analyzed samples, α-CD inclusion complexes exhibited the strongest antibacterial activity. Furthermore, 1 and α-CD formed inclusion complexes at a molar ratio of 1:1. The improved water-solubilities and good antibacterial activity of the inclusion complexes will allow for their future application against foodborne pathogens.
- 著者
- Sho NISHIKAWA Misa KAMIYA Hiroki AOYAMA Kazuki YOSHIMURA Ryo MIYATA Shigenori KUMAZAWA Takanori TSUDA
- 出版者
- Center for Academic Publications Japan
- 雑誌
- Journal of Nutritional Science and Vitaminology (ISSN:03014800)
- 巻号頁・発行日
- vol.65, no.4, pp.328-334, 2019-08-31 (Released:2019-08-31)
- 参考文献数
- 42
- 被引用文献数
- 9
Classical brown adipocytes, characterized by interscapular depots, have multilocular fat depots and are known to release excess energy. Recent studies have shown that induction of brown-like adipocytes, also referred to as beige or brite cells, in white adipose tissue (WAT) results in the release of excess energy through mitochondrial heat production via uncoupling protein 1. This has potential a therapeutic strategy for obesity and related diseases as well as classical brown adipocytes. In our previous studies, we found that artepillin C (ArtC, 10 mg/kg body weight), a characteristic constituent of Brazilian propolis, significantly induced the development of brown-like adipocytes in inguinal WAT (iWAT) of mice. Furthermore, we recently demonstrated that curcumin (Cur, 4.5 mg/kg) also significantly induced the development of brown-like adipocytes in mice. The combined administration of several food-derived factors can enhance their bioactivity and reduce their required functional doses. In this study, we showed that co-administration of Cur and ArtC at lower doses (Cur, 1.5 mg/kg; ArtC, 5 mg/kg) additively induce brown-like adipocyte development in mouse iWAT. Moreover, this induction is associated with the localized production of norepinephrine following accumulation of alternatively activated macrophages in iWAT. These findings suggest that co-administration of Cur and ArtC is significantly effective to reduce the dose and enhance the formation of brown-like adipocyte via a unique molecular mechanism.