著者

Watari Hiromi Nakajima Hiroya Atsuumi Wataru Nakamura Takanori Nanya Takeshi Ise Yuji Sakai Ryuichi

出版者

Elsevier

雑誌

Comparative biochemistry and physiology Part C : Toxicology & pharmacology (ISSN:15320456)

巻号頁・発行日

vol.221, pp.82-88, 2019-07

被引用文献数

7

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We screened 868 marine extracts in search of hematopoietic molecules resulted in findings of several extracts that proliferated Ba/F3-HuMpl cells but not the cells expressed with other hematopoietic cytokine receptors, EPO and G-CSF. Separation of the most potent extract of a Micronesian sponge Corticium sp., guided by the cell proliferation assay using Ba/F3-HuMpl cells resulted in an isolation of thrombocorticin (ThC), a novel 14 kDa protein as an active principal. ThC displayed concentration-dependent proliferation of Ba/F3-HuMpl cells, and had a stronger activity than that of eltrombopag, a small molecule drug used to treat thrombocytopenia. ThC induced phosphorylation of STAT5, suggesting that it activates Jak/STAT pathway as in the case of TPO. These results together indicated that ThC is a specific agonist for c-Mpl, although the size and shape differs largely from TPO. Here we present isolation, characterization and biological activity of ThC.

著者

MITSUNARI Shigeo SAKAI Ryuichi KASAHARA Masao

出版者

一般社団法人電子情報通信学会

雑誌

IEICE transactions on fundamentals of electronics, communications and computer sciences (ISSN:09168508)

巻号頁・発行日

vol.85, no.2, pp.481-484, 2002-02-01

被引用文献数

35

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A traitor tracing scheme is a broadcast encryption scheme in which a provider can trace malicious authorized users who illegally gave their personal keys to unauthorized users. The conventional schemes have some problems; one of them is that there exists an upper bound on the sizes of keys to certify the security of the scheme against a collusion attack by many traitors, and so that the size of the header increases according to the increase of the bound. We shall propose a new traitor tracing scheme where the header size is independent of the number of traitors.