著者

中村 早希 三浦 麻子 Saki Nakamura Asako Miura

雑誌

人文論究 (ISSN:02866773)

巻号頁・発行日

vol.64, no.2, pp.59-77, 2014-09-20

著者

Sayuko Shiraishi Tamami Haraguchi Saki Nakamura Honami Kojima Ikuo Kawasaki Miyako Yoshida Takahiro Uchida

出版者

公益社団法人日本薬学会

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.65, no.2, pp.151-156, 2017-02-01 (Released:2017-02-01)

参考文献数

31

被引用文献数

9

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The purpose of the study was to evaluate suppression of the bitterness intensity of bitter basic drugs by chlorogenic acid (CGA) using the artificial taste sensor and human gustatory sensation testing and to investigate the mechanism underlying bitterness suppression using 1H-NMR. Diphenhydramine hydrocholoride (DPH) was the bitter basic drug used in the study. Quinic acid (QNA) and caffeic acid (CFA) together form CGA. Although all three acids suppressed the bitterness intensity of DPH in a dose-dependent manner as determined by the taste sensor and in gustatory sensation tests, CFA was less effective than either CGA or QNA. Data from 1H-NMR spectroscopic analysis of mixtures of the three acids with DPH suggest that the carboxyl group, which is present in both QNA and CGA but not CFA, interact with the amine group of DPH. This study showed that the bitterness intensity of DPH was suppressed by QNA and CGA through a direct electrostatic interaction with DPH as confirmed in 1H-NMR spectroscopic analysis. CGA and QNA may therefore be useful bitterness-masking agents for the basic drug DPH.

著者

中村 早希 三浦 麻子 Saki Nakamura Asako Miura

出版者

関西学院大学人文学会

雑誌

人文論究 (ISSN:02866773)

巻号頁・発行日

vol.64, no.2, pp.59-77, 2014-09

著者

中村 早希 三浦 麻子 Saki Nakamura Asako Miura

出版者

関西学院大学人文学会

雑誌

人文論究 (ISSN:02866773)

巻号頁・発行日

vol.64, no.2, pp.59-77, 2014-09