- 著者
- 山本 聡美 Satomi Yamamoto
- 雑誌
- 共立女子大学・共立女子短期大学総合文化研究所紀要 = Bulletin of Center for Interdisciplinary Studies of Science and Culture, Kyoritsu Women's University & Junior College
- 巻号頁・発行日
- vol.24, pp.140-186, 2018-02
- 著者
- 山本 聡美 Satomi Yamamoto
- 雑誌
- 共立女子大学・共立女子短期大学総合文化研究所紀要 = Bulletin of Center for Interdisciplinary Studies of Science and Culture, Kyoritsu Women's University & Junior College
- 巻号頁・発行日
- vol.24, pp.140-186, 2018-02 (Released:2018-03-09)
- 著者
- Taishi TANABE Yurina FUKUDA Kazuhiko KAWASHIMA Satomi YAMAMOTO Takashige KASHIMOTO Hisaaki SATO
- 出版者
- JAPANESE SOCIETY OF VETERINARY SCIENCE
- 雑誌
- Journal of Veterinary Medical Science (ISSN:09167250)
- 巻号頁・発行日
- pp.20-0182, (Released:2020-11-27)
Alpha-amanitin, one of the amatoxins in egg amanita, has a cyclic peptide structure, and was reported as having antiviral activity against several viruses. We investigated whether α-amanitin has antiviral activity against feline immunodeficiency virus (FIV). FL-4 cells persistently infected with FIV Petaluma were cultured with α-amanitin. Reverse transcriptase (RT) activity in the supernatant of FL-4 cells was significantly inhibited by α-amanitin. In addition, the production of FIV core protein in FL-4 cells was inhibited by α-amanitin when analyzed by western blotting. Furthermore, α-amanitin inhibited the transcription of FIV in real-time RT-PCR. These data suggested that α-amanitin showed anti-FIV activity by inhibiting the RNA transcription level.