著者

上田 敏 Satoshi UEDA

出版者

大手前女子短期大学・大手前栄養文化学院・大手前ビジネス学院

雑誌

大手前女子短期大学・大手前栄養文化学院・大手前ビジネス学院研究集録 = Reseach of Otemae Junior College, Otemae College of Nutrition, Otemae Business College (ISSN:09103767)

巻号頁・発行日

no.8, pp.23-34, 1988-10-15

著者

上田 敏 Satoshi UEDA

出版者

大手前女子短期大学・大手前栄養文化学院・大手前ビジネス学院

雑誌

大手前女子短期大学・大手前栄養文化学院・大手前ビジネス学院研究集録 = Reseach of Otemae Junior College, Otemae College of Nutrition, Otemae Business College (ISSN:09103767)

巻号頁・発行日

vol.8, pp.023-034, 1988-10-15

著者

Yuko CHIBA Katsuhiko SATOH Satoshi UEDA Nobuo KANAZAWA Yoshiaki TAMURA Toshiyuki HORIUCHI

出版者

The Japan Endocrine Society

雑誌

Endocrine Journal (ISSN:09188959)

巻号頁・発行日

vol.54, no.3, pp.379-383, 2007 (Released:2007-07-19)

参考文献数

21

被引用文献数

14 26

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Psychosomatic symptoms in primary hyperparathyroidism (PHPT) are various and include such conditions as obsessive-compulsive disorder, depression, anxiety, and paranoia. In the elderly the clinical features of the disease are often non-specific and difficult to diagnose. To quantify subjective symptoms of patients with hyperparathyroidism in the elderly, we determined whether these clinical manifestations resolved after surgical parathyroidectomy (PTX) in three PHPT patients over eighty years old. They were diagnosed with hypercalcemia, hypophosphatemia, high PTH concentrations, and osteoporosis. A single parathyroid adenoma was confirmed in each patient by Tc-MIBI scintigram, neck ultrasonography and computed tomographic scanning. PTX was performed in these three patients. Assessments of psychologic symptoms, using the Hamilton Rating Scale for Depression (HAM-D), serum calcium, and intact PTH were obtained before and after PTX. Mean weight of the resected adenomas was 438 ± 138 mg (mean ± SD). After PTX, serum calcium decreased from 11.1 ± 0.5 to 9.2 ± 0.5 mg/dl and intact PTH from 160.0 ± 25.2 to 45.3 ± 22.2 pg/ml. Total HAM-D scores in each patient decreased from 45 to 9, 17 to 1 and 15 to 5, respectively. Especially, there were marked improvements in depressive mood, psychomotor inhibition, anxiety and somatic symptoms after PTX. The quality of life in those patients was also improved by PTX. We propose here that PTX in elderly PHPT patients with psychiatric symptoms should be considered instead of oral administration, such as anti-depressants or bisphosphonates.