著者

Shohei Dobashi Chinatsu Aiba Daisuke Ando Masataka Kiuchi Mitsuya Yamakita Katsuhiro Koyama

出版者

The Japanese Society of Physical Fitness and Sports Medicine

雑誌

The Journal of Physical Fitness and Sports Medicine (ISSN:21868131)

巻号頁・発行日

vol.7, no.4, pp.239-245, 2018-07-25 (Released:2018-07-18)

参考文献数

40

被引用文献数

2 2

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Both exercise training and chronic caloric restriction contribute to brain health through enhanced expression of brain-derived neurotrophic factor (BDNF). This study investigated the synergistic effects between 12-week low-intensity exercise training and caloric restriction on hippocampal BDNF expression with redox status in rats. Twenty-six, 7-week-old male Wistar rats were randomly divided into the following 4 groups: (1) sedentary control (Con, n = 7), (2) exercise (Ex, n = 6), (3) caloric restriction (CR, n = 7), and (4) caloric restriction and exercise training (ExCR, n = 6). Although Con and Ex rats were fed ad libitum over time, CR and ExCR rats consumed 40% less food compared to Con rats. Ex and ExCR rats underwent low-intensity treadmill running (30 min/day, 5 days/week). Forty-eight hours after the termination of the 12-week intervention, rats were sacrificed and the hippocampus was quickly dissected for measuring BDNF expression and markers of oxidative stress, including 4-hydroxy-2-nonenal (4-HNE). Hippocampal BDNF expression was significantly increased in Ex compared to Con rats (p = 0.007), whereas the exercise-induced increase in BDNF was completely suppressed by a combination with caloric restriction. Furthermore, we observed a significant relationship between hippocampal BDNF and 4-HNE expression (r = 0.725, p < 0.001). Our findings indicate that exercise training combined with caloric restriction might not have a synergistic effect on hippocampal BDNF expression in young rats. Moreover, exercise-induced oxidative stress can trigger BDNF expression in the hippocampus.

著者

Shohei Dobashi Arisa Nakamura Kyohei Saito Daisuke Ando Katsuhiro Koyama

出版者

The Japanese Society of Physical Fitness and Sports Medicine

雑誌

The Journal of Physical Fitness and Sports Medicine (ISSN:21868131)

巻号頁・発行日

vol.8, no.4, pp.181-184, 2019-07-25 (Released:2019-07-17)

参考文献数

11

被引用文献数

2

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The purpose of this study was to investigate the impact of acute exercise and hypoxic exposure on the level of circulating selenoprotein P (SeP), which is known to cause insulin and exercise resistance, and expression of the muscle peroxisome proliferator-activated receptor-γ co-activator-1α (PGC-1α) gene in pre-diabetes rat models. Fifteen week old male Wistar rats (n = 20) were fed with a high-fat diet and water ad libitum for 3 weeks. After the acclimation period, they were assigned to sedentary or exercise groups under normoxic (20.9% O2) and hypoxic (14.5% O2) conditions. Each of the exercise groups (NE and HE) was administered two 30-min no-load swimming exercises with an interval of 5-min rest. The serum, the liver, and the triceps muscle were obtained 3 h after the exercises. Hypoxic exposure did not affect hepatic SeP mRNA, serum SeP protein, and muscle PGC-1α mRNA expression. In contrast, acute swimming exercise reduced circulating SeP concentration and increased PGC-1α mRNA expression in triceps muscle. In conclusion, acute swimming exercise rather than moderate hypoxic exposure might improve insulin and exercise resistance in pre-diabetes conditions for type 2 diabetes.