著者

Chaojie Zhang Koichi Shirahata Shuji Suzuki Yutaka Akiyama Satoshi Matsuoka

雑誌

研究報告計算機アーキテクチャ(ARC)

巻号頁・発行日

vol.2014-ARC-213, no.29, pp.1-7, 2014-12-02

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Homology search to be used in emerging bioinformatics problems such as metagenomics is of increasing importance and challenge as its application area grows more broadly while the computational complexity is increasing, thus requiring massive parallel data processing. Earlier work by some of the authors have devised novel algorithms such as GHOSTX, but the master-worker parallelization to enumerate and schedule for data processing was done with a privately developed, MPI-based master-worker framework called GHOST-MP. An alternative is to utilize the now-popular big data software substrates, such as MapReduce with abundant associated software tool-chains, but it is not clear whether the massive resource required by metagenomic homology search would not overwhelm its known limitations. By converting the GHOST-MP master-worker data processing pipeline to accommodate MapReduce, and benchmarking them on a variety of high-performance MapReduce incarnations including Hadoop and Spark, we attempt to characterize the appropriateness of MapReduce as a generic framework for metagenomics that embody extremely resource consuming requirements for both compute and data.

著者

Fumitaka TAKAHASHI Takaharu HAKOZAKI Nobuo KANNO Shuji SUZUKI Yasuji HARADA Satoshi SOETA Shinichi NAKAMURA Shinya YAMAGUCHI Yasushi HARA

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.21-0315, (Released:2022-04-05)

被引用文献数

1

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We evaluated the completeness of bony fusion of the atlantoaxial joint (AAJ) through polymethylmethacrylate fixation (PMF) and atlantoaxial plate fixation (APF) using six canine models with dens partial resection. In both groups, the hydroxyapatite content at the AAJ was measured up to 7 months postoperatively using quantitative computed tomography. Histological assessment revealed fibrous fusion in the PMF group. Meanwhile, in the APF group, only one dog achieved fibrous fusion, whereas the remaining three showed bony fusion. To our knowledge, this study was the first to evaluate AAJ fusion histologically after PMF and APF. The present study demonstrates that PMF and APF may stabilize the AAJ without clinical complications. Therefore, PMF and APF are clinically useful fixation methods for atlantoaxial instability.

著者

Sachiyo TANAKA Hitomi SHIBUYA Shuji SUZUKI Nobuo KANNO Yasuji HARADA Asaka SATO Satoshi SOETA Yasushi HARA

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.20-0401, (Released:2020-12-02)

被引用文献数

7

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This study aimed to assess the structural and functional effects of long-term hyperglucocorticoidemia on canine myocardium and compare these parameters with histopathological changes. Twelve healthy male beagle dogs were enrolled and assigned to the high-dose prednisolone (P; n=6) and control (C; n=6) groups. The P group was treated with 2 mg/kg of prednisolone BID for 84 days. Clinical parameters were measured using echocardiography and non-invasive systolic blood pressure (SBP) measured before the initiation of synthetic corticosteroids and at 7, 28, 56, and 84 days after the start of medication. For histological evaluation, cardiovascular tissue was harvested from dogs in groups P (at the end of the medication period) and C (scheduled to be euthanized for unrelated reasons). In the P group, clinical changes including thickening of the left ventricular free wall (LVFW) and interventricular septum (IVS), decreased left ventricular (LV) diastolic function, and increased SBP were observed after the start of medication. During histological evaluation, fibrosis was observed in the LVFW and IVS in the P group. Furthermore, decreased glucocorticoid receptor (GCR) levels were observed in the LVFW, right ventricular free wall (RVFW), and IVS and increased mineralocorticoid receptor (MCR) levels were observed in the LVFW and RVFW in the P group compared with those in the C group. In conclusion, fibrosis may cause LV structural and functional abnormalities in dogs with hyperadrenocorticism. Furthermore, GCR downregulation and upregulated MCR might influence the myocardial fibrosis.

著者

Masakazu SHIMADA Nichika MIZOKAMI Tom ICHINOHE Nobuo KANNO Shuji SUZUKI Takuya YOGO Yasuji HARADA Yasushi HARA

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.19-0613, (Released:2020-05-25)

被引用文献数

16

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The object of this study is to evaluate the long-term outcome of hind limb weight-bearing function and progression of stifle osteoarthritis (OA) after tibial plateau leveling osteotomy (TPLO). Groups were classified by the degree of cranial cruciate ligament (CrCL) damage and presence or absence of medial meniscus damage as macroscopically evaluated during surgery. Weight-bearing function was assessed via the peak vertical force (PVF), and OA progression was assessed via the radiographic OA score (OAS) preoperatively and 1, 3, 6, 12, 18, 24, and 36 months postoperatively. In all stifles, PVF was significantly higher within 6 months postoperatively than preoperatively, and this high ratio was maintained for 36 months. The OAS was significantly higher 24 months postoperatively than preoperatively in stifles with a partial CrCL tear, and significantly increased at each timepoint after 3 months postoperatively in stifles with complete CrCL rupture. The OAS remained consistently lower in stifles with a partial CrCL tear and no treatment of the medial meniscus than in stifles with complete rupture. Thus, after TPLO, the weight-bearing function improved in the early postoperative period and was maintained for as long as 36 months. Although OA progressed over time after TPLO, the progression was more gradual in stifles with partial tears than in those with complete rupture. Canine patients would benefit from earlier surgical intervention through development of technology that enables early detection of ligament degeneration.

著者

Fumitaka TAKAHASHI Takaharu HAKOZAKI Shigenori KOUNO Shuji SUZUKI Asaka SATO Nobuo KANNO Yasuji HARADA Shinya YAMAGUCHI Yasushi HARA

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.17-0438, (Released:2018-02-05)

被引用文献数

5

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We compared clinical outcomes after ventral fixation in dogs with atlantoaxial instability (AAI) on the basis of the presence or absence of atlantooccipital overlapping (AOO). Of 41 dogs diagnosed with AAI and treated ventral fixation, 12 exhibited AOO (AOO group), whereas 29 did not (non-AOO group). The AOO group had significantly higher neurological scores before (P=0.024) and 1 month after (P=0.033) surgery compared with the non-AOO group; however, no significant differences were observed between the groups 2 months after surgery. The presence of complicating AOO affected the clinical signs for dogs with AAI, but did not directly affect the outcome of surgical stabilization of AAI.

著者

Ryuji FUKUSHIMA Rieko YOSHIYUKI Noboru MACHIDA Hirotaka MATSUMOTO Soomin KIM Lina HAMABE Hsu HUAI-CHE Toshiharu FUKAYAMA Shuji SUZUKI Derya AYTEMIZ Ryo TANAKA Yoshihisa YAMANE

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.12-0319, (Released:2013-04-05)

被引用文献数

1 5

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A four-month-old female Labrador retriever was brought to the Tokyo University of Agriculture and Technology Animal Medical Center for examination of its main symptoms of cough, tachypnea and exercise intolerance. Upon examination, the dog was found to have cyanosis and inadequate growth. Echocardiography revealed tetralogy of Fallot. Cardiac catheterization confirmed that the main pulmonary artery was completely occluded and that blood flowed from the aorta to the pulmonary artery. Accordingly, the animal was diagnosed with extreme tetralogy of Fallot.