- 著者
- 木村 駿介 大石 和男 キムラ シュンスケ オオイシ カズオ Shunsuke Kimura Kazuo Oishi
- 出版者
- 立教大学コミュニティ福祉研究所
- 雑誌
- 立教大学コミュニティ福祉研究所紀要 = Journal of the Institute of Community & Human Services, Rikkyo University (ISSN:24322636)
- 巻号頁・発行日
- no.4, pp.1-16, 2016-11
- 著者
- 木村 駿介 大石 和男 キムラ シュンスケ オオイシ カズオ Shunsuke Kimura Kazuo Oishi
- 出版者
- 立教大学コミュニティ福祉研究所
- 雑誌
- 立教大学コミュニティ福祉研究所紀要 = Journal of the Institute of Community & Human Services, Rikkyo University (ISSN:24322636)
- 巻号頁・発行日
- no.4, pp.17-33, 2016-11
- 著者
- Masako YAJIMA Shin-Ichiro KARAKI Takeshi TSURUTA Shunsuke KIMURA Junko NIO-KOBAYASHI Atsukazu KUWAHARA Takaji YAJIMA
- 出版者
- バイオメディカルリサーチプレス
- 雑誌
- Biomedical Research (ISSN:03886107)
- 巻号頁・発行日
- vol.37, no.5, pp.319-328, 2016-10-01 (Released:2016-10-25)
- 参考文献数
- 41
- 被引用文献数
- 13
Non-neuronal and atropine-sensitive ileal contractile responses to short chain fatty acids (SCFAs) are detected in the neonatal stage, and change with age or inflammatory conditions. However, the roles of luminal SCFAs in developmental changes have not yet been elucidated. We examined ileal contractile responses to SCFAs in mice colonized with different SCFA-producing intestinal microbiota under normal and inflammatory conditions. Using conventional (Conv), germ-free (GF), and gnotobiotic mice infected with Bifidobacterium (GB-bif), Propionibacterium (GB-prop), or Lactobacillus (GB-lact), ileal contractions were measured in 1-day-old neonates and 7-week-old mice using an isotonic transducer. Contractions occurred in all 1-day-old neonates, and were significantly desensitized in the adult stage in the Conv, GB-bif, and GB-prop groups, but not in the GF and GB-lact groups. An injection of lipopolysaccharide frequently restored desensitized contractions; however, the contraction rate did not change in the GF and GB-lact groups. The relative mRNA expression of a SCFA receptor (GPR43) or nicotinic acetylcholine receptor α7 was weaker in the GF group (0.3-fold or 0.4-fold expression level, respectively) than in the Conv group. In conclusion, the luminal inhabitation of SCFA-producing bacteria may potentiate the regulation of non-neuronal and atropine-sensitive ileal contractile responses to SCFAs under healthy and inflammatory conditions.
- 著者
- Yohsuke NAMBU Masashi MIURA Ryosuke YOSHIZAWA Toshishige HAGIHARA Shunsuke KIMURA Akira YUMIYAMA Satoru IGARASHI
- 出版者
- THE JAPAN SOCIETY FOR AERONAUTICAL AND SPACE SCIENCES
- 雑誌
- TRANSACTIONS OF THE JAPAN SOCIETY FOR AERONAUTICAL AND SPACE SCIENCES, AEROSPACE TECHNOLOGY JAPAN (ISSN:18840485)
- 巻号頁・発行日
- vol.14, no.ists30, pp.Pt_15-Pt_24, 2016 (Released:2016-11-26)
This research aims to develop a web application to realize open model-based collaboration (Open MBC), which is a framework to support efficient and collaborative development of complex systems. We describe the concept of Open MBC and the features of the web application. Furthermore, we introduce an actual case, presenting requirements analysis and management to use the application in the CubeSat project at Osaka Prefecture University. Feedback from students described the difficulty of systems engineering and functional weaknesses prevented the use of our application. Based on this feedback, the paper proposes improvements to functions and operation methods.
- 著者
- 木村 駿介 大石 和男 キムラ シュンスケ オオイシ カズオ Shunsuke Kimura Kazuo Oishi
- 雑誌
- 立教大学コミュニティ福祉研究所紀要
- 巻号頁・発行日
- vol.4, pp.1-16, 2016-11
- 著者
- 木村 駿介 大石 和男 キムラ シュンスケ オオイシ カズオ Shunsuke Kimura Kazuo Oishi
- 雑誌
- 立教大学コミュニティ福祉研究所紀要
- 巻号頁・発行日
- vol.4, pp.17-33, 2016-11