著者

田渕 史 渡部 祥山 Stanislav L. Karsten 籔内 研佑 佐原 義基 髙里 実 藤本 和也 横川 隆司

出版者

一般社団法人 電気学会

雑誌

電気学会論文誌E(センサ・マイクロマシン部門誌) (ISSN:13418939)

巻号頁・発行日

vol.143, no.9, pp.306-312, 2023-09-01 (Released:2023-09-01)

参考文献数

14

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Main function of glomerulus is to filter plasma and waste products from blood. The filtration function is known to be impaired and irreversibly damaged by a disease or a drug administration. Therefore, nephrotoxicity assessment is essential for a new drug development. However, conventional animal models for drug screening cannot appropriately assess toxicity of drugs to human glomerulus. In this study, we constructed a glomerulus-on-a-chip using human podocytes and evaluated the selectivity of inulin and albumin for filtration function.