著者

Dushica PAVLOVICH Pepa UZUNOVA Tanja GALABOVA Vanja PENEVA Zanca SOKOLOVA Dushica KORACEVIC Rumen TSANEV Stefan RIBAROV

出版者

SOCIETY FOR FREE RADICAL RESEARCH JAPAN

雑誌

Journal of Clinical Biochemistry and Nutrition (ISSN:09120009)

巻号頁・発行日

vol.11, no.3, pp.171-182, 1991 (Released:2010-02-25)

参考文献数

32

被引用文献数

2 3

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It was found that the products of lipid peroxidation in liver homogenates, isolated from paracetamol-treated rats and incubated in presence of Fe2+, are significantly lower than those in homogenates from the control rats. The Fe2+-induced chemiluminescence in these homogenates was also inhibited. The capacity of liver homogenates isolated from phenobarbital+paracetamol-treated rats to undergo Fe2+-catalyzed lipid peroxidation with light emission was decreased with respect to both rats treated with phenobarbital and control rats. Using a phospholipid liposome suspension in which was initiated lipid peroxidation by Fe2+, we found that paracetamol possesses concentration-dependent antioxidant action. Paracetamol inhibited also the luminol and lucigenin-dependent chemiluminescence in the xanthine-xanthine oxidase system. In such system for generation of superoxide radicals, paracetamol suppressed the reduction of nitro blue tetrazolium to formazan.The results obtained showed that paracetamol has antioxidant activity, which may be due to its ability to scavenge lipid and superoxide radicals.