著者

Suguru Yoshida Takamitsu Hosoya

出版者

(社)日本化学会

雑誌

Chemistry Letters (ISSN:03667022)

巻号頁・発行日

vol.44, no.11, pp.1450-1460, 2015-11-05 (Released:2015-11-05)

参考文献数

159

被引用文献数

173 1

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Recent developments in aryne chemistry are reviewed with a particular focus on synthetic methods. This includes an overview of the precursors of arynes and their activators; the generation of arynes with functional groups and their ensuing reactivities; and the novel transformations achieved via aryne intermediates. These newly developed methods have enabled the synthesis of a variety of previously inaccessible aromatic compounds, allowing the construction of a diversity-enriched chemical library that will further facilitate future drug discoveries.

著者

Suguru Yoshida Takamitsu Hosoya

出版者

(社)日本化学会

雑誌

Chemistry Letters (ISSN:03667022)

巻号頁・発行日

pp.150839, (Released:2015-09-12)

被引用文献数

173

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Recent developments in aryne chemistry are reviewed with a particular focus on synthetic methods. This includes an overview of the precursors of arynes and their activators; the generation of arynes with functional groups and their ensuing reactivities; and the novel transformations achieved via aryne intermediates. These newly developed methods have enabled the synthesis of a variety of previously inaccessible aromatic compounds, allowing the construction of a diversity-enriched chemical library that will further facilitate future drug discoveries.

著者

Suguru Yoshida Takamitsu Hosoya

出版者

(社)日本化学会

雑誌

Chemistry Letters (ISSN:03667022)

巻号頁・発行日

vol.42, no.6, pp.583-585, 2013-06-05 (Released:2013-06-05)

参考文献数

34

被引用文献数

57

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Arynes, generated in situ from o-(trimethylsilyl)aryl triflates by treatment with a fluoride, have been shown to react efficiently with various alkoxyphosphines via a mechanism similar to the Michaelis–Arbuzov reaction. Diverse aromatic oxophosphorus compounds, including derivatives with an ortho-ester function, have become easily available from a common aryne precursor by this method.