- 著者
- Takei Toshiharu Odake Hiroshi Miura Kazuaki TAKAGI Yutaka
- 出版者
- Japan Oil Chemists' Society
- 雑誌
- Journal of Oleo Science (ISSN:13458957)
- 巻号頁・発行日
- vol.55, no.3, pp.121-126, 2006
- 被引用文献数
- 4
This paper reports the ecotoxicological study of "tetradecanoic acid, 2-sulfo-, 1-methylester, sodium salt (C14MES)". This salt was synthesized by sulfonating 1-methyl tetradecanoic acid derived from palm oil and coconut oil with sulfur trioxide. The tests were attempted in accordance with the OECD (Organization for Economic Cooperation and Development) Guidelines for the Testing of Chemicals. The 72 h ErC<sub>50</sub> exceeded 100 mg/L in the alga growth inhibition test. In the daphnia acute immobilization and reproduction tests, 17.2 mg/L of 48 h EC<sub>50</sub> and 4.10 mg/L of NOEC were derived, respectively. These ecotoxicities of C14MES were equivalent to or lower than that of other similar anionic surfactants, such as LAS (linear alkylbenzene sulfonate) or AOS (alpha olefin sulfonate).<br>
- 著者
- Sato Jun Yamamoto Yasuhito Nakamura Tsuneaki ISHIDA Shigeru TAKAGI Yutaka
- 出版者
- 日本毒性学会
- 雑誌
- Journal of toxicological sciences (ISSN:03881350)
- 巻号頁・発行日
- vol.30, no.4, pp.339-347, 2005-12-21
- 被引用文献数
- 2 3
We evaluated the toxicity of tetradecanoic acid methyl ester sodium salt (C14-MES), a major component of fabric detergents, following the test guidelines of the Organization for Economic Cooperation and Development. The rat acute oral LD_<50> was 1,000 mg/kg in males and 500 mg/kg in females. Applying the combined repeated dose and reproductive/developmental toxicity screening test (ReproTox), we exposed groups of Crj:CD (SD) IGS rats to C14-MES in the diet at concentrations of 0, 0.3, 0.6, or 1.2%. We observed decreases in fibrinogen levels and longer prothrombin time at the 1.2% treated level in females and decreases in serum triglyceride levels in both sexes at the 0.6% and 1.2% treatment levels, but the effects were not clinically significant. The no-observed-effect-level (NOEL) for repeated dose toxicity was 0.3% (175 mg/kg body weight/day for males, 249 for females). The NOEL for reproduction/developmental toxicity was 1.2% (740 mg/kg for males, 1039 for females). C14-MES was negative in the reverse gene mutation assay and the chromosomal aberration test and did not induce skin sensitization in the guinea pig maximization test. These data confirm that C14-MES is of low hazard potential.