著者

Toshiki Fukui Kazuhiro Yamauchi Mie Maruyama Youichi Abe Sumie Yoshitaka Tadashi Yasuda

出版者

Japan Society of Ningen Dock

雑誌

Ningen Dock International (ISSN:21878072)

巻号頁・発行日

vol.2, no.2, pp.70-75, 2015 (Released:2018-12-10)

参考文献数

24

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Objective: We previously reported the usefulness of brachial-ankle pulse wave velocity (baPWV) based on a cross-sectional analysis of data from Ningen Dock and general health screening. In our previous studies, we observed a strong relationship between the clustering of atherosclerosis risk factors and baPWV. In the present study, to evaluate this relationship further, we performed a longitudinal analysis over a 10-year period.Methods: Of the 22,377 individuals in whom baPWV was measured using form ABI/PWV at our facility, 626 males with measurements in both the first year and the 10th year were selected as subjects. Results: A significant positive correlation was observed between baPWV and the number of atherosclerosis risk factors in the first year of measurement, similar to our previous study. Over 10 years, the amount of change in all 626 males was about 100 cm/sec and the number of atherosclerosis risk factors increased from 1.3 to 1.6. The change in baPWV over 10 years tended to be smaller the greater the number of atherosclerosis risk factors. However, the values of baPWV in the 10th year were still higher when there were a greater number of risk factors. Conclusion: It is significant to measure baPWV continuously and pay attention to changes in it since it may be possible to suppress increases in baPWV by reducing the number of atherosclerosis risk factors. Furthermore, our findings suggest that early interventions in atherogenic risk control are required to reduce increases in the stiffness of large arteries.

著者

Eiseki Usami Michio Kimura Tomoaki Yoshimura Tadashi Yasuda Hitomi Teramachi Tadashi Sugiyama Teruo Tsuchiya

出版者

日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.38, no.5, pp.282-287, 2012-05-10 (Released:2013-05-10)

参考文献数

14

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Steroids are used in the treatment of patients with non-Hodgkin's lymphoma (NHL) as a one off high dose and are a key antitumor medication. Although the duration of steroid administration is short, Steroid Withdrawal Syndrome (SWS) has been documented after treatment. The aim of this retrospective study was to evaluate the prevalence of SWS and to assess the relevance of steroid tapering in 116 patients newly diagnosed with NHL. The most significant symptoms of SWS documented were fatigue in 70 patients (60.3%) and anorexia in 32 (27.6%). Four elderly patients (3.4%) suffered with serious SWS symptoms of grade 3. Of the 70 patients suffering with SWS, 22 went on to receive tapered steroid therapy during the subsequent chemotherapy treatment. The average steroid tapering period was 4.4 days and 86.4%patients reported a significant improvement of their SWS symptoms. No serious adverse events were noted. Although age did not appear to be a risk factor of SWS it was noted that elderly patients with SWS were more adversely affected.We conclude that steroid tapering is a safe and effective treatment method. If the patient has serious symptoms of SWS we should introduce steroid tapering aggressively and early, especially in elderly patients.