- 著者
- Toshiki Fukui Kazuhiro Yamauchi Mie Maruyama Youichi Abe Sumie Yoshitaka Tadashi Yasuda
- 出版者
- Japan Society of Ningen Dock
- 雑誌
- Ningen Dock International (ISSN:21878072)
- 巻号頁・発行日
- vol.2, no.2, pp.70-75, 2015 (Released:2018-12-10)
- 参考文献数
- 24
Objective: We previously reported the usefulness of brachial-ankle pulse wave velocity (baPWV) based on a cross-sectional analysis of data from Ningen Dock and general health screening. In our previous studies, we observed a strong relationship between the clustering of atherosclerosis risk factors and baPWV. In the present study, to evaluate this relationship further, we performed a longitudinal analysis over a 10-year period.Methods: Of the 22,377 individuals in whom baPWV was measured using form ABI/PWV at our facility, 626 males with measurements in both the first year and the 10th year were selected as subjects. Results: A significant positive correlation was observed between baPWV and the number of atherosclerosis risk factors in the first year of measurement, similar to our previous study. Over 10 years, the amount of change in all 626 males was about 100 cm/sec and the number of atherosclerosis risk factors increased from 1.3 to 1.6. The change in baPWV over 10 years tended to be smaller the greater the number of atherosclerosis risk factors. However, the values of baPWV in the 10th year were still higher when there were a greater number of risk factors. Conclusion: It is significant to measure baPWV continuously and pay attention to changes in it since it may be possible to suppress increases in baPWV by reducing the number of atherosclerosis risk factors. Furthermore, our findings suggest that early interventions in atherogenic risk control are required to reduce increases in the stiffness of large arteries.
- 著者
- Koutaro Yokote Kiyoshi Niwa Tomomi Hakoda Fumiki Oh Yoshitaka Kajimoto Toshiki Fukui Hyosung Kim Yoshinori Noda Torbjörn Lundström Toshitaka Yajima
- 出版者
- The Japanese Circulation Society
- 雑誌
- Circulation Journal (ISSN:13469843)
- 巻号頁・発行日
- pp.CJ-19-0358, (Released:2020-04-11)
- 参考文献数
- 27
- 被引用文献数
- 5
Background:This study is the first to evaluate the short-term efficacy and long-term safety of AZD0585, a mixture of omega-3 free fatty acids, in Japanese patients with dyslipidemia.Methods and Results:In this randomized double-blind placebo-controlled Phase III study, 383 patients were randomized to 2 g AZD0585, 4 g AZD0585, or placebo once daily for 52 weeks. Eligible patients had low-density lipoprotein cholesterol (LDL-C) levels controlled regardless of statin use, and triglyceride levels between 150 and 499 mg/dL. The least-squares (LS) mean percentage changes in triglyceride concentrations from baseline to the 12-week endpoint (mean of measurements at Weeks 10 and 12) in the 2 and 4 g AZD0585 and placebo groups were −15.57%, −21.75%, and 11.15% respectively (P<0.0001 for both AZD0585 doses vs. placebo). No clinically significant changes from baseline to the 12-week endpoint in total cholesterol, LDL-C, and LDL-C/apolipoprotein (Apo) B were found with AZD0585. High-density lipoprotein cholesterol (HDL-C) was slightly increased and very low-density lipoprotein cholesterol, non-HDL-C, ApoC-II, and ApoC-III were decreased with AZD0585 compared with placebo at the 12-week endpoint. Lipid profiles up to Week 52 were consistent with those up to the 12-week endpoint. No clinically important safety concerns were raised.Conclusions:AZD0585 significantly decreased serum triglyceride levels compared with placebo at the 12-week endpoint and was generally safe and well tolerated in Japanese patients with dyslipidemia.