- 著者
- Takeshi Watanabe Kaoru Kawasaki Trang T.H Tu Takayuki Suga Shiori Sugawara Lou Mikuzuki Anna Miura Yukiko Shinohara Tatsuya Yoshikawa Miho Takenoshita Akira Toyofuku Takahiko Nagamine
- 出版者
- The Japanese Society of Clinical Neuropsychopharmacology
- 雑誌
- Clinical Neuropsychopharmacology and Therapeutics (ISSN:18848826)
- 巻号頁・発行日
- vol.9, pp.12-14, 2018-04-10 (Released:2018-04-10)
- 参考文献数
- 5
- 被引用文献数
- 2 3
- 著者
- Takahiko NAGAMINE Yoshinobu MATSUMOTO Masaru NAKAMURA
- 出版者
- BMFH Press
- 雑誌
- Bioscience of Microbiota, Food and Health (ISSN:21863342)
- 巻号頁・発行日
- vol.38, no.1, pp.31-33, 2019 (Released:2019-01-23)
- 参考文献数
- 17
- 被引用文献数
- 13
The incidence of Clostridium difficile infection (CDI) is greater in elderly orthopedic patients. We conducted a retrospective case-control study by selecting elderly patients who underwent proximal femoral fracture surgery to investigate the effect of probiotics on CDI prevention. Cases were diagnosed with CDI by an enzyme-linked immunosorbent assay for C. difficile toxins using frozen stool specimens. The primary method of exposure was receipt of combination probiotics such as Streptococcus faecalis, Bacillus mesentericus, and Clostridium butyricum. The crude odds ratio between developing CDI and receiving combination probiotics was 0.074 (95% CI: 0.010–0.565; p=0.002). Adjunctive combination probiotics among elderly patients who undergo proximal femoral fracture surgery likely reduces the probability of CDI.
- 著者
- Riwa Ozasa Tetsuya Okada Satomi Nadanaka Takahiko Nagamine Alisha Zyryanova Heather Harding David Ron Kazutoshi Mori
- 出版者
- 日本細胞生物学会
- 雑誌
- Cell Structure and Function (ISSN:03867196)
- 巻号頁・発行日
- vol.38, no.2, pp.183-195, 2013 (Released:2013-08-08)
- 参考文献数
- 39
- 被引用文献数
- 6 30
Patients with schizophrenia receive medication to alleviate various symptoms, but some efficacious second generation antipsychotics, particularly olanzapine, can cause obesity, dyslipidemia, and diabetes mellitus. It has been generally considered that olanzapine contributes to the development of diabetes by inducing obesity and subsequent insulin resistance. In this study, we examined the effect of olanzapine and risperidone, another second generation antipsychotic, on a hamster pancreatic β cell line, and found that both evoked mild endoplasmic reticulum (ER) stress, as evidenced by mild activation of the ER stress sensor molecule PERK. Surprisingly, only olanzapine induced marked apoptosis. Phosphorylation of the α subunit of eukaryotic initiation factor 2, an event immediately downstream of PERK activation, was not observed in cells treated with olanzapine, protein synthesis continued despite PERK activation, and ER stress was thereby sustained. Secretion of insulin was markedly inhibited, and both proinsulin and insulin accumulated inside olanzapine-treated cells. Inhibition of protein synthesis and knockdown of insulin mRNA, which result in less unfolded protein burden, both attenuated subsequent olanzapine-induced apoptosis. Given clinical observations that some patients taking olanzapine exhibit hyperlipidemia and hyperglycemia without gaining weight, our observations suggest that damage to pancreatic β cells may contribute to the undesirable metabolic consequences of olanzapine treatment in some cases.