- 著者
- Sae Aratani Takeshi Matsunobu Takahiro Kawai Hirotake Suzuki Norihiro Usukura Kimihiro Okubo Yukinao Sakai
- 出版者
- The Keio Journal of Medicine
- 雑誌
- The Keio Journal of Medicine (ISSN:00229717)
- 巻号頁・発行日
- vol.70, no.1, pp.19-23, 2021 (Released:2021-03-25)
- 参考文献数
- 21
- 被引用文献数
- 1 4
Proton pump inhibitors (PPIs) are widely used medicines worldwide. However, a rare etiology of syndrome of inappropriate secretion of antidiuretic hormone (SIADH) related to PPI was recently reported. Therefore, the putative role of PPIs in SIADH cannot be underestimated. A 78-year-old Japanese woman was admitted to our hospital for treatment of left Bell’s palsy. On admission, the patient was oriented with normal laboratory data, including a serum Na level of 135 mEq/L. Oral glucocorticoids and a proton pump inhibitor were initiated in combination with oral valaciclovir. Six days later, the patient’s consciousness became impaired. Laboratory data showed a serum Na level of 103 mEq/L, a urine Na level of 64.8 mEq/L, a urine K level of 43.6 mEq/L, and a urine osmolality of 450 mOsm/kg H2O. The patient met the criteria for SIADH. The initial treatment included water restriction and 3% hypertonic saline administration. The cessation of PPI significantly improved the urine diluting capacity and concomitantly increased serum Na, which indicated that the use of PPI had been responsible for the etiology of SIADH. The present case illustrates that physicians need to be aware of the uncommon adverse effects of PPI, such as SIADH.
- 著者
- Haruna SAWAGUCHI Jiale XU Takahiro KAWAI Takashi MINETA Yoshimune NONOMURA
- 出版者
- 公益社団法人 日本セラミックス協会
- 雑誌
- Journal of the Ceramic Society of Japan (ISSN:18820743)
- 巻号頁・発行日
- vol.124, no.6, pp.753-756, 2016-06-01 (Released:2016-06-01)
- 参考文献数
- 16
- 被引用文献数
- 4
Apatite-coated silicon wafers are expected to be utilized for novel biosensors or implants. However, the mechanism and optimum conditions for the formation of an apatite layer on silicon wafer surfaces are unclear. Herein, we examined the effect of pretreating silicon wafers with titanium sputtering and weak alkali aqueous solutions before immersing them in a simulated body fluid (SBF). A week after immersion, silicon wafer surfaces coated with thin titanium layers were covered by hemispherical apatite particles that were produced in a heterogeneous nucleation reaction, whereas untreated silicon wafer surfaces were covered by spherical particles that were produced in a homogeneous reaction. Pretreatment of titanium-coated silicon wafers with 0.1 M NaOH aqueous solution assured heterogeneous apatite formation. Both titanium-coated and untreated silicon wafers were fully covered by the apatite layer after soaking in the SBF for 2–3 weeks. These findings show that pretreatment of silicon wafers with titanium sputtering and weak alkali aqueous solution is effective for obtaining apatite-coated silicon wafers.
- 著者
- Haruna Sawaguchi Hiroshi Nishida Takahiro Kawai Hiroyuki Mayama Yoshimune Nonomura
- 出版者
- (社)日本化学会
- 雑誌
- Chemistry Letters (ISSN:03667022)
- 巻号頁・発行日
- pp.150005, (Released:2015-02-14)
- 被引用文献数
- 1
We prepared an apatite/polymer composite material with a fractal surface by transferring the hierarchical rough surface of a plaster replica onto calcium phosphate paste and immersing the paste in buffer. The rough structure (fractal dimension = 2.3) accelerated the spreading and penetration of a water droplet placed on the surface. This material can be applied in dental implants and texture testers.