- 著者
- Hikaru Horii Manaho Matsubara Kenji Sasaoka Takahiro Yamamoto
- 出版者
- The Japan Society of Vacuum and Surface Science
- 雑誌
- e-Journal of Surface Science and Nanotechnology (ISSN:13480391)
- 巻号頁・発行日
- vol.19, pp.125-130, 2021-12-23 (Released:2021-12-23)
- 参考文献数
- 40
- 被引用文献数
- 1
The thermoelectric response of bilayer graphene over a wide temperature range (0 < T ≤ 400 K) was theoretically investigated using linear response theory combined with a Green's function technique. We found that the power factor PF for a fixed chemical potential μ exhibits a maximum at a certain T. On the other hand, we found that the PF for a fixed T exhibits a maximum (PFmax) at an optimal μ [or optimal carrier concentration (nopt)]. In addition, we clarified the T dependence of nopt and PFmax and explained the existence of nopt in terms of the thermal excitation of electrons between the valence and conduction bands, which cannot be predicted by the conventional Mott formula.
- 著者
- Ryohei Aoyagi Takahiro Yamamoto Yuuki Furukawa Makoto Arita
- 出版者
- The Pharmaceutical Society of Japan
- 雑誌
- Chemical and Pharmaceutical Bulletin (ISSN:00092363)
- 巻号頁・発行日
- vol.69, no.10, pp.953-961, 2021-10-01 (Released:2021-10-01)
- 参考文献数
- 99
Polyunsaturated fatty acids (PUFAs), esterified to phospholipids, are susceptible to oxidation. They form oxidized phospholipids (OxPLs) by oxygenases or reactive oxygen species (ROS), or both. These OxPLs are associated with various diseases, such as atherosclerosis, pulmonary injuries, neurodegenerative diseases, cancer, and diabetes. Since many types of OxPLs seem to be generated in vivo, precise determination of their structural diversity is required to understand their potential structure-specific functions. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is a powerful method to quantitatively measure the structural diversity of OxPLs present in biological samples. This review outlines recent advances in analytical methods for OxPLs and their physiological relevance in health and diseases.
- 著者
- Hideo Sasai Nobuyuki Shimozawa Takahiko Asano Norio Kawamoto Takahiro Yamamoto Takeshi Kimura Minako Kawamoto Eiko Matsui Toshiyuki Fukao
- 出版者
- 東北ジャーナル刊行会
- 雑誌
- The Tohoku Journal of Experimental Medicine (ISSN:00408727)
- 巻号頁・発行日
- vol.237, no.4, pp.323-327, 2015 (Released:2015-12-04)
- 参考文献数
- 11
- 被引用文献数
- 2 9
Cystathionine β-synthase (CBS) deficiency, well known as classical homocystinuria, is a rare autosomal recessive inborn error of homocysteine and sulfur metabolism. CBS converts homocysteine to cystathionine. The clinical features of untreated CBS deficiency include myopia, ectopia lentis, mental retardation, skeletal anomalies resembling Marfan syndrome, and thromboembolic events. Cerebral white matter lesions (CWMLs), identified in magnetic resonance imaging (MRI), are related to various clinical conditions including ischemia, inflammation, demyelination, infection, a tumor, and metabolic disorders such as phenylketonuria. The presence of CWMLs is, however, believed to be a very rare condition in CBS-deficient patients. Herein, we report reversible CWMLs associated with hypermethioninemia caused by poor protein restriction and betaine therapy in a 21-year-old male with pyridoxine-nonresponsive CBS deficiency. T2-weighted images (T2WI) and fluid-attenuated inversion-recovery (FLAIR) images showed diffuse high signal intensity in subcortical areas extending to the deep white matter. Diffusion-weighted images (DWI) showed high signal intensity, while apparent diffusion coefficient (ADC) map demonstrated decreased ADC value in the lesions. The course of improvement after correct methionine restriction was successively followed by brain MRI. The CWMLs had regressed at 1 month after restriction, and disappeared after 5 months. ADC values were very low before proper methionine restriction, but normalized after 2 months. Use of betaine in the presence of elevated plasma methionine may increase the risk of reversible CWMLs in some CBS-deficient patients.