著者

Kayo Yasuda Masaki Miyazawa Takamasa Ishii Naoaki Ishii

出版者

SOCIETY FOR FREE RADICAL RESEARCH JAPAN

雑誌

Journal of Clinical Biochemistry and Nutrition (ISSN:09120009)

巻号頁・発行日

vol.73, no.3, pp.173-177, 2023 (Released:2023-11-01)

参考文献数

58

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The molecular mechanism of aging, which has been a “black box” for many years, has been elucidated in recent years, and the nematode C. elegans, which is a model animal for aging research, has played a major role in its elucidation. From the analysis of C. ‍elegans longevity-related mutant genes, many signal trans­duction systems, with the insulin/insulin-like growth factor signal transduction system at the core, have emerged. It has become clear that this signal transduction system is greatly affected by external nutrients and is involved in the downstream regulation of oxidative stress, which is considered to be one of the main causes of aging.