著者

Takashi UNO Kouichi ISOBE Naoyuki UENO Ataru FUKUDA Satoshi SUDO Hiroaki SHIROTORI Isao KITAHARA Takanori FUKUSHIMA Hisao ITO

出版者

Journal of Radiation Research 編集委員会

雑誌

Journal of Radiation Research (ISSN:04493060)

巻号頁・発行日

vol.51, no.4, pp.449-454, 2010 (Released:2010-07-29)

参考文献数

12

被引用文献数

12 3

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The objective of this retrospective study was to report initial results of CyberKnife stereotactic radiotherapy (SRT) boost for tumors in the head and neck area. Between March 2008 and August 2009, 10 patients were treated with SRT boost using CyberKnife system due mainly to unfavorable condition such as tumors in close proximity to serial organs or former radiotherapy fields. Treatment sites were the external auditory canal in two, the nasopharynx in one, the oropharynx in three, the nasal cavity in one, the maxillary sinus in two, and the oligometastatic cervical lymph node in one. All patients underwent preceding conventional radiotherapy of 40 to 60 Gy. Dose and fractionation scheme of the Cyberknife SRT boost was individualized, and prescribed dose ranged from 9 Gy to 16 Gy in 3 to 4 fractions. Among four patients for whom dose to the optic pathway was concerned, the maximum dose was only about 3 Gy for three patients whereas 9.6 Gy in the remaining one patient. The maximum dose for the mandible in one of three patients with oropharyngeal cancer was 19.7 Gy, whereas majority of the bone can be spared by using non-isocentric conformal beams. For a patient with nasopharyngeal cancer, the highest dose in the brain stem was 15 Gy. However, majority of the brain stem received less than 40% of the maximum dose. Although a small volume high dose area within the normal structure could be observed in several patients, results of the present study showed potential benefits of the CyberKnife SRT boost.

著者

Takanori Suzuki Takuma Kuroda Hitomi Tamaoki Sho Higasa Ryo Katoono Kenshu Fujiwara Takanori Fukushima Hidetoshi Yamada

出版者

(社)日本化学会

雑誌

Chemistry Letters (ISSN:03667022)

巻号頁・発行日

vol.42, no.7, pp.706-708, 2013-07-05 (Released:2013-07-05)

参考文献数

29

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Upon oxidation of the title heterocycles with dimethylamino groups, elemental sulfur is extruded to form dicationic dyes, which regenerate the heterocycles by the reaction with Na2S. The electrolysis of the heterocycles induces a drastic change in UV–vis spectrum exhibiting several isosbestic points. The bay-region substituents enhance configurational stability, so the optically pure heterocycle can be obtained in terms of helicity of one-handedness, and its chromism is accompanied by a large chiroptical response as detected by CD spectroscopy.

著者

Takanori Suzuki Hitomi Tamaoki Ryo Katoono Kenshu Fujiwara Junji Ichikawa Takanori Fukushima

出版者

(社)日本化学会

雑誌

Chemistry Letters (ISSN:03667022)

巻号頁・発行日

vol.42, no.7, pp.703-705, 2013-07-05 (Released:2013-07-05)

参考文献数

24

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Octafluorobiphenyl-2,2′-diylbis(diarylmethylium) dye 2a2+ prepared from 1,2-dibromotetrafluorobenzene is interconvertible with colorless dihydrophenanthrene donor 1a. By the SNAr reactions of 1a with acetylides, π-extended analogues 1b and 1c were obtained. Their electrochromic behavior is accompanied by a drastic absorption change not only in the visible but also UV region, because the torsion angle of the biaryl unit is modified upon redox reactions.