著者

Hirotaka Muraoka Takashi Kaneda Naohisa Hirahara Kotaro Ito Shunya Okada Takumi Kondo

出版者

Japanese Society for Magnetic Resonance in Medicine

雑誌

Magnetic Resonance in Medical Sciences (ISSN:13473182)

巻号頁・発行日

pp.mp.2021-0153, (Released:2022-03-11)

参考文献数

30

被引用文献数

1

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Purpose: Chronic diffuse sclerosing osteomyelitis (CDSO) is a non-suppurative inflammatory bone disease diagnosed based on combined clinical, histopathological, and radiological findings. Accurate diagnosis is important since CDSO is more refractory to treatment than suppurative osteomyelitis. The purpose of this study was to determine the diagnostic efficacy of diffusion-weighted imaging (DWI) in the quantitative assessment of CDSO to distinguish it from acute suppurative osteomyelitis (ASO) and chronic suppurative osteomyelitis (CSO) of the mandible.Methods: Using a retrospective cohort study design, we analyzed MRI data of 6 patients with CDSO and 34 patients with ASO and CSO. The mean apparent diffusion coefficient (ADC) values of the three groups (CDSO, ASO, and CSO groups) were calculated, and differences were analyzed using Kruskal–Wallis and post-hoc Mann–Whitney tests with Bonferroni adjustments. We performed a receiver operating characteristic (ROC) curve analysis to evaluate the ability of the ADC to predict CDSO. P < 0.05 was considered statistically significant.Results: The mean ADCs in the CDSO, ASO, and CSO groups were 1.22 ± 0.04 × 10–3 mm2/s, 1.28 ± 0.08 × 10–3 mm2/s, and 1.06 ± 0.09 × 10–3 mm2/s, respectively. Significant differences were observed between the ASO and CSO groups (P < 0.001) and CSO and CDSO groups (P < 0.01). However, there was no significant difference between the ASO and CDSO groups (P = 0.21). The ROC analysis revealed a cut-off ADC value of 1.19 for distinguishing the CSO group from the CDSO group. Sensitivity, specificity, accuracy, and area under the ROC curve were 1.0, 0.92, 0, 95, and 0.94, respectively.Conclusion: The results suggest that ADC may be useful in distinguishing CDSO from mandibular suppurative osteomyelitis.

著者

Kenshiro FUJIMOTO Hiroko OHMURA Takashi KANEDA

出版者

Japan Society for Bioscience, Biotechnology, and Agrochemistry

雑誌

Agricultural and Biological Chemistry (ISSN:00021369)

巻号頁・発行日

vol.50, no.1, pp.101-108, 1986 (Released:2006-04-05)

参考文献数

34

被引用文献数

2

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The biological antioxidant activities of bromophenols (5-bromo-3, 4-dihydroxy benzaldehyde and 5-bromo-3, 4-dihydroxy benzylalcohol), protocatechualdehyde and vanillyl octadecanamide were compared with α-tocopherol in vitro and in vivo. All of these antioxidants significantly inhibited the lipid peroxidation in microsomal suspensions induced by ascorbate/Fe(II) or NADPH. By removing the non-binding free antioxidants from the suspensions, the inhibitory activities markedly decreased in antioxidants other than α-tocopherol; however, considerable activity was still observed. The effects of orally administered antioxidants on the symptoms of vitamin E deficiency were examined using rats fed with a vitamin E-free diet and supplemented with oxidized oils. As a result and contrary to the effects in vitro, all of the antioxidants were much less effective in liver. However, some of the vitamin E-deficient symptoms such as organic solvent-soluble fluorescent materials in the heart and lung, and oxidative hemolysis were significantly suppressed by some antioxidants.