- 著者
- Pey-Yu Wang Takashi Kaneko Yuan Wang Masato Tawata Akio Sato
- 出版者
- Tohoku University Medical Press
- 雑誌
- The Tohoku Journal of Experimental Medicine (ISSN:00408727)
- 巻号頁・発行日
- vol.189, no.1, pp.59-70, 1999 (Released:2005-07-05)
- 参考文献数
- 17
- 被引用文献数
- 6 11
Some normal people are falsely classified as having impaired glucose tolerance (IGT) if they are given an oral glucose tolerance test (OGTT) when their last meal contained very few carbohydrates. In this study, the duration of carbohydrate restriction was extended to one and three days and the relationship between the carbohydrate restriction and the glucose tolerance after an OGTT was examined. Two different groups of normal subjects were placed on high-carbohydrate (80% carbohydrates) and low-carbohydrate (10%) diets before an OGTT; one group for one day and the other for 3 days. None of the subjects showed impairment of glucose tolerance when placed on the high-carbohydrate regimens. In contrast, 3 of 12 subjects and 2 of 8 subjects placed on the low-carbohydrate diets for 1 and 3 days, respectively, were classified as having IGT. The impairment of glucose tolerance was invariably accompanied by an increase in the fasting plasma free fatty acid level. The longer the period of carbohydrate restriction, the severer was the glucose tolerance impairment. However, the number of subjects who were classified as having IGT did not depend on the duration of carbohydrate restriction. The impairment of glucose tolerance after carbohydrate restriction may be associated with the Randle effect, which is the activation of the glucose-free fatty acid cycle.
- 著者
- Youichi OHKUBO Chieko KADOSIMA Takashi KANEKO Junichi CHUCHIYA Yosiaki AKUTSU Masamitu TAMURA Tadao YOSHIDA
- 出版者
- Japan Society for Atmospheric Environment
- 雑誌
- Journal of Japan Society of Air Pollution (ISSN:03867064)
- 巻号頁・発行日
- vol.25, no.3, pp.212-220, 1990-05-10 (Released:2011-11-08)
- 参考文献数
- 17
- 被引用文献数
- 2
シガレヅトスモーク中には高反応性で見かけ上長寿命の気相ラジラルが存在することが見いだされている。このラジカルの生体への有害性に関する基礎的な知見を得るため, シガレットスモークおよびスモーク中の気相ラジカル生成をモデル化したオレフィン/NO/空気系反応ガスが生体膜の主要構成脂質である高度不飽和脂酸 (PUFA) の自動酸化を開始することを共役ジエン生成法および酸素吸収法を用いて検討した。その結果, シガレットスモークは主としてその気相ラジカルによりPUFAの自動酸化を開始し, 生体に有害な過酸化物を生成することを見いだした。