著者
Nobuyoshi Ozawa Kiyoshi Ito Toru Tase Daisuke Shibuya Hirohito Metoki Nobuo Yaegashi
出版者
Tohoku University Medical Press
雑誌
The Tohoku Journal of Experimental Medicine (ISSN:00408727)
巻号頁・発行日
vol.243, no.4, pp.329-334, 2017 (Released:2017-12-20)
参考文献数
13

The Japanese national immunization programme for Human Papillomavirus (HPV) started in 2010. Vaccination rates increased up to 70% in women in the 1996-1999 birth. However, the proactive recommendation for HPV vaccine was suspended in 2013, following repeated media reports of adverse events. Vaccination rates plumped to less than 1% in women born since 2002. In this study, incidence of abnormal cytology and histology was examined in terms of HPV vaccination among 5,924 women aged 20 to 24 years in the fiscal year (FY) 2014 and 2015. The total rate of vaccination was 16.9% (1,002/5,924). In case of FY 2015, the rates of vaccination were 59.26%, 49.68%, 11.97%, 9.08%, and 4.58% in those aged 20, 21, 22, 23, and 24 years old, respectively. The rates of high-grade squamous intraepithelial lesion (HSIL) or worse were 0.20% (2/1,002) in women with HPV vaccination and 1.14% (56/4,922) in those without HPV vaccination, indicating a significant reduction of 82.46% with vaccination (P < 0.0001). The rates of cervical intraepithelial neoplasia (CIN) 1+ were 0.80% (8/1,002) in women with vaccination and 2.28% (112/4,922) in those without vaccination. The reduction rate of CIN1+ was 64.91% (P = 0.0025). The rates of CIN2+ were 0.10% (1/1,002) with vaccination and 0.69% (34/4,922) without vaccination. The reduction rate of CIN2+ was 85.51% (P = 0.0261). Our data are the first to demonstrate a significant reduction of CIN2+ cases in an Asian population. Scientific discussion is needed to restart the proactive recommendation for HPV vaccine in Japan.
著者
Kayo Sakamoto Yoshitaka Minamidate Takayuki Nagai
出版者
Tohoku University Medical Press
雑誌
The Tohoku Journal of Experimental Medicine (ISSN:00408727)
巻号頁・発行日
vol.225, no.2, pp.77-80, 2011 (Released:2011-09-08)
参考文献数
4
被引用文献数
2 or 0

On March 11, 2011 at 14:46 (Friday), a massive magnitude-9.0 earthquake attacked large areas of northeastern Japan, including Sendai City. The huge earthquake generated catastrophic tsunamis, leading to unprecedented disasters in the seacoast areas of the Tohoku region (about 20,000 dead and missing persons). Upon this earthquake, in Tohoku University Medical Library, a 3-storey earthquake-resistant building, most of books fell down from bookshelves on the second and third floors, but the bookshelves remained steady because of the effective fixation. Many piles of fallen books blocked up the walkways and the narrow passages between the bookshelves; namely, books are easily transformed to dangerous weapons in a shaking building. Fortunately, all library staffs and users evacuated outside the building without even a scratch. Importantly, we were able to open the first floor of the Medical Library on March 14 (Monday), because the first floor has been used for the Learning Commons, with open space for group meetings. We thus provided students, medical staffs, and faculty members with the comfortable place during the early stage of the disasters. In fact, medical staffs and faculty members worked hard over weekend to deal with many patients and clear the post-quake confusions. Moreover, electricity, gas, or water supply was not yet restored in most areas of Sendai City. In the earthquake-prone zones, the Medical Library should function as a facility that not only enhances information gathering but also provides the place like an oasis of relaxation for students and medical staffs upon great earthquakes.
著者
Hisanori Fukunaga Akinari Yokoya Yasuyuki Taki Kevin M. Prise
出版者
Tohoku University Medical Press
雑誌
The Tohoku Journal of Experimental Medicine (ISSN:00408727)
巻号頁・発行日
vol.242, no.1, pp.77-81, 2017 (Released:2017-05-27)
参考文献数
32

On March 11, 2011, a devastating earthquake and subsequent tsunami caused serious damage to areas of the Pacific coast in Fukushima prefecture and prompted fears among the residents about a possible meltdown of the Fukushima Daiichi Nuclear Power Plant reactors. As of 2017, over six years have passed since the Fukushima nuclear crisis and yet the full ramifications of the biological exposures to this accidental release of radioactive substances remain unclear. Furthermore, although several genetic studies have determined that the variation in radiation sensitivity among different individuals is wider than expected, personalized medical approaches for Fukushima victims have seemed to be insufficient. In this commentary, we discuss radiobiological issues arising from low-dose radiation exposure, from the cell-based to the population level. We also introduce the scientific utility of the Integrative Japanese Genome Variation Database (iJGVD), an online database released by the Tohoku Medical Megabank Organization, Tohoku University that covered the whole genome sequences of 2,049 healthy individuals in the northeastern part of Japan in 2016. Here we propose a personalized radiation risk assessment and medical approach, which considers the genetic variation of radiation sensitivity among individuals, for next-step developments in radiological protection.
著者
TSUJI ICHIRO NAKAMURA RYUICHI
出版者
Tohoku University Medical Press
雑誌
The Tohoku Journal of Experimental Medicine (ISSN:00408727)
巻号頁・発行日
vol.155, no.3, pp.225-232, 1988

TSUJI, I. and NAKAMURA, R. <i>Time Course of Tension Development of Knee</i> <i>Extensor Muscle on Twitch, Tetanic, and Fast Voluntary Contraction in Normal</i> <i>Subjects</i>. Tohoku J. exp. Med., 1988, <b>155</b> (3), 225-232 - Tension lag time (TLT), a latency from the onset of electromyographic activities of prime mover muscle to the rise of tension, of knee extensor muscle was measured at twitch, tetanic, and fast voluntary contraction in three normal subjects. Twitch and tetanic contractions were evoked by four different strengths of electrical stimuli, and the peak tensions attained at fast voluntary contraction were within the range of tensions evoked by electrical stimulation. In each mode of contraction, the relationship between TLT and peak tension (F<sub>max</sub>) was approximated by a hyperbolic function of F<sub>max</sub> (TLT-a)=b. TLT was influenced by three factors: (1) F<sub>max</sub>, the greater F<sub>max</sub>, the shorter TLT; (2) force detection level to point out timing of the rise of tension, the higher the level, the longer TLT was; and (3) the mode of contraction, shortest at the twitch, longest at the voluntary, and intermediate in the tetanic contraction.
著者
Mami Ishikuro Sergio Ramón Gutiérrez Ubeda Taku Obara Toshihide Saga Naofumi Tanaka Chiyo Oikawa Keisei Fujimori
出版者
Tohoku University Medical Press
雑誌
The Tohoku Journal of Experimental Medicine (ISSN:00408727)
巻号頁・発行日
vol.243, no.3, pp.195-203, 2017 (Released:2017-11-28)
参考文献数
16

Patient falls are common adverse medical events in hospitals. The objectives of this study were to clarify the factors of patient falls at hospitalization or transfer to another ward, which could be assumed that patients experience new environment. Patients who were hospitalized or transferred to another ward at a hospital in Japan, between January 14 and February 14, 2014 were included. We used a risk assessment sheet and applied stepwise regression analysis to identify factors of patient falls. We also investigated changes in patient conditions on the risk assessment sheet by the chi-square test. A total of 1,362 patients (53.2% female; mean age, 57.1 ± 18.0 years) were eligible for analysis, and 38 (2.8%) fell during the study period. The fallers were significantly older than the non-fallers (63.8 ± 18.0 vs. 56.9 ± 18.7 years, P = 0.03), but no significant difference was seen in sex (55.3% vs. 53.1% female). “History of falls”, “Tubes inserted”, “Need assistance/supervision for toileting” and “Excretion more than two times per night” were significantly related to patient falls (adjusted odds ratios [95% confidence interval]: 2.41 [1.05-5.53], 3.64 [1.57-8.43], 4.52 [2.00-10.23] and 3.92 [1.38-11.09]). Among 30 fallers, “Overestimation or non-understanding of own physical abilities” was significantly more frequent after falls (30.0%) than before falls (6.7%, P = 0.02). The factors found in this study might be useful for identifying patients at higher risk of falls.
著者
YOSHIDA YOSHIRO SATO TETSUO KANO ICHIKI FUKUDA MORIKUNI SASAKI TAKASHI HOSHINO HISAO TANAKA MOTONAO TERASAWA YOSHIO
出版者
Tohoku University Medical Press
雑誌
The Tohoku Journal of Experimental Medicine (ISSN:00408727)
巻号頁・発行日
vol.123, no.4, pp.329-335, 1977

Four patients with endocardial fibroelastosis were studied by two-dimensional and M-mcde echocardiography. The two-dimensional echocardiography showed the characteristic echo from the abnormally thickened endocardium of the left ventricle in every case. Of the 4 cases, 2 were still suffering from congestive heart failure at the time of the study and the other 2 had been already free from clinical symptoms. In the former group, the ultrasonic findings revealed an enlargement of the left ventricle (large left ventricular dimension index) and poor movement of the anterior mitral leaflet which was indicated by a decrease in the diastolic descent rate. The latter group presented almost normal findings concerning the above points. The ultrasonic method is thus proved to be very useful for the diagnosis and evaluation of clinical conditions in cases of endocardial fibroelastosis.
著者
MARINKOVIC Slobodan STOSIC-OPINCAL Tatjana STRBAC Mile TOMIC Irina TOMIC Oliver DJORDJEVIC Drago
出版者
Tohoku University Medical Press
雑誌
Tohoku journal of experimental medicine (ISSN:00408727)
巻号頁・発行日
vol.222, no.4, pp.297-302, 2010-12-01

Radiology has attracted the world of art with the esthetic value of its images, and as a new medium for the artistic expression. In order to investigate the links between neuroradiology and art, we examined 12,763 artworks presented in corresponding publications and in Google images on the Internet. The selected artworks were created by 1,964 authors. To give our own contribution to this field, we produced several artful radiological images using the X-ray of 4 cerebral hemispheres, one dissected brain, serial sections of one head and brain, the vascular casts of 2 brains, the magnetic resonance imaging (MRI) scans of one volunteer, and various options in Photoshop. Among the examined artworks, neuroradiological images were used in 129 artworks (1.01%) that were created by 31 artists (1.58%). The artists applied different radiological techniques: X-ray, angiography, computed tomography (CT), multislice CT, MRI, functional MRI, positron emission tomography (PET) or single-photon emission computed tomography (SPECT), either alone or in various combinations. They used the original images, i.e. radiographs or scans, or their electronic modifications in Photoshop or three-dimensional (3D) software. Some artworks presented the skull, yet others the brain, and still others both, either with or without a head image. The neuroradiological artworks were created as paintings, photographs, digital works and sculptures. Their authors were professional artists, designers, amateurs and radiologists. In conclusion, thanks to the esthetics of some radiological images and the valuable creations of certain artists, neuroradiology has become an important field of contemporary art.
著者
Kim Junghoon Tanabe Kai Yoshizawa Yasuyo Yokoyama Noriko Suga Yoko Kuno Shinya
出版者
Tohoku University Medical Press
雑誌
Tohoku journal of experimental medicine (ISSN:00408727)
巻号頁・発行日
vol.229, no.1, pp.11-17, 2013
被引用文献数
0 or 5

Regular physical activity is associated with improvements of metabolic syndrome (MetS) risk factors. Furthermore, recent physical activity guidelines for health promotion recommend that moderate to vigorous physical activity should be performed in bouts lasting ≥ 10 min. Brisk walking is a popular and readily attainable form of moderate intensity physical activity and is suitable for the majority of individuals. However, it is unclear whether brisk walking lasting ≥ 10 min is associated with improvement in MetS. This study aimed to determine the effects of a 1-year lifestyle-based physical activity intervention with brisk walking of ≥ 10 min using a pedometer on the improvement in MetS. Three hundred and seventy-six overweight male employees with ≥ 1 MetS component(s) participated in this intervention study from 2008 to 2009 (age, 30-62 years; body mass index, 23.0-45.5 kg/m2). Overall, 316 participants (84%) completed the 1-year intervention. MetS was defined according to the Japanese criteria at baseline and after 1 year. Brisk walking lasting ≥ 10 min was significantly associated with the decrease in waist circumference (β = −1.479) and triglyceride (β = −31.260), and the increase in high-density lipoprotein cholesterol (β = 2.117). The brisk walking step counts were also significantly associated with higher odds for an improvement in MetS (OR, 1.48; 95% CI, 1.05-2.09) and abdominal obesity (OR, 1.45; 95% CI, 1.12-1.87). In conclusion, the lifestyle-based intervention with brisk walking of ≥ 10 min is an effective strategy to improve MetS in overweight male employees.
著者
Mio Ishibashi Hideki Tonori Takeo Miki Eriko Miyajima Yasushi Kudo Masashi Tsunoda Kou Sakabe Yoshiharu Aizawa
出版者
Tohoku University Medical Press
雑誌
The Tohoku Journal of Experimental Medicine (ISSN:00408727)
巻号頁・発行日
vol.211, no.3, pp.223-233, 2007 (Released:2007-03-09)
参考文献数
26
被引用文献数
6 or 0

Sick house syndrome (SHS) is a Japanese concept derived from sick building syndrome (SBS), however SHS includes a broader scope of sickness than does SBS. Symptoms of SHS/SBS disappear after leaving the sick house/building, while symptoms of multiple chemical sensitivity (MCS) are elicited by the chance of chemical exposure after leaving the sick house/building. To establish the concept of SHS, we propose to introduce a new classification for SHS. A total of 214 patients complaining of SHS and/or MCS were independently classified using a new classification by clinical ecologists who are experienced physicians with expert knowledge of clinical ecology and general physicians according to disease pathogenesis from clinical records. The classification is as follows: type 1 (symptoms of chemical intoxication), type 2 (symptoms developed possibly due to chemical exposure), type 3 (symptoms developed not because of chemical exposure but rather because of psychological or mental factors), and type 4 (symptoms developed due to allergies or other diseases). The agreements on the classification made by clinical ecologists and general physicians reached 77.1% (Cohen's kappa = 0.631), suggesting that this new classification was both apt and accurate. Relations between SHS and allergy/MCS were also studied. The cases classified as SHS type 4 more frequently had allergic past histories than did other types. The proportion of possible MCS cases was higher in the chemical induced SHS group (types 1 and 2) than in other types among male patients. For the universal use in clinical practice, it is necessary to prepare helpful diagnostic criteria of this SHS classification based on pathogenesis and carry our study forward all over the country.