- 著者
- Tasuku Hara Kohei Oka Naoto Iwai Yutaka Inada Toshifumi Tsuji Takashi Okuda Akihiro Nagata Toshiyuki Komaki Keizo Kagawa
- 出版者
- The Japanese Society of Internal Medicine
- 雑誌
- Internal Medicine (ISSN:09182918)
- 巻号頁・発行日
- vol.60, no.3, pp.417-421, 2021-02-01 (Released:2021-02-01)
- 参考文献数
- 29
- 被引用文献数
- 10
A 54-year-old woman underwent chemotherapy including rituximab and autologous peripheral blood stem cell transplantation (auto-PBSCT) for diffuse large B-cell lymphoma. Before the treatment, she exhibited a resolved hepatitis B virus (HBV) infection. She was diagnosed with HBV reactivation based on positive serum HBV-DNA test results, 55 months after her last treatment. Subsequently, he was treated with tenofovir alafenamide fumarate (TAF) therapy and her liver function improved. Patients undergoing chemotherapy including rituximab and auto-PBSCT are at a high risk of HBV reactivation. In such cases, careful and long-term observations may be required to detect HBV reactivation.
- 著者
- Yu Ichida Kaname Matsue Takashi Okuda Sakamoto
- 出版者
- The Japan Society for Industrial and Applied Mathematics
- 雑誌
- JSIAM Letters (ISSN:18830609)
- 巻号頁・発行日
- vol.12, pp.65-68, 2020 (Released:2020-10-12)
- 参考文献数
- 10
- 被引用文献数
- 3
In this paper, we consider the asymptotic behavior of traveling wave solutions of a certain degenerate nonlinear parabolic equation for $\xi \equiv x - ct \to - \infty$ with $c>0$. We give a refined one of them, which was not obtained in the preceding work [Ichida-Sakamoto, J. Elliptic and Parabolic Equations, to appear], by an appropriate asymptotic study and properties of the Lambert $W$ function.
- 著者
- Hiroko P. Indo Hsiu-Chuan Yen Ikuo Nakanishi Ken-ichiro Matsumoto Masato Tamura Yumiko Nagano Hirofumi Matsui Oleg Gusev Richard Cornette Takashi Okuda Yukiko Minamiyama Hiroshi Ichikawa Shigeaki Suenaga Misato Oki Tsuyoshi Sato Toshihiko Ozawa Daret K. St. Clair Hideyuki J. Majima
- 出版者
- 日本酸化ストレス学会
- 雑誌
- Journal of Clinical Biochemistry and Nutrition (ISSN:09120009)
- 巻号頁・発行日
- pp.14-42, (Released:2014-12-23)
- 参考文献数
- 90
- 被引用文献数
- 36 232
Fridovich identified CuZnSOD in 1969 and manganese superoxide dismutase (MnSOD) in 1973, and proposed ”the Superoxide Theory,” which postulates that superoxide (O2•−) is the origin of most reactive oxygen species (ROS) and that it undergoes a chain reaction in a cell, playing a central role in the ROS producing system. Increased oxidative stress on an organism causes damage to cells, the smallest constituent unit of an organism, which can lead to the onset of a variety of chronic diseases, such as Alzheimer’s, Parkinson’s, amyotrophic lateral sclerosis and other neurological diseases caused by abnormalities in biological defenses or increased intracellular reactive oxygen levels. Oxidative stress also plays a role in aging. Antioxidant systems, including non-enzyme low-molecular-weight antioxidants (such as, vitamins A, C and E, polyphenols, glutathione, and coenzyme Q10) and antioxidant enzymes, fight against oxidants in cells. Superoxide is considered to be a major factor in oxidant toxicity, and mitochondrial MnSOD enzymes constitute an essential defense against superoxide. Mitochondria are the major source of superoxide. The reaction of superoxide generated from mitochondria with nitric oxide is faster than SOD catalyzed reaction, and produces peroxynitrite. Thus, based on research conducted after Fridovich’s seminal studies, we now propose a modified superoxide theory; i.e., superoxide is the origin of reactive oxygen and nitrogen species (RONS) and, as such, causes various redox related diseases and aging.