著者

Takeshi HARADA Seiji IIDA Yoshiki INADA Susumu TANAKA Yoshinosuke HAMADA Mikihiko KOGO

出版者

Nano Biomedical Society

雑誌

Nano Biomedicine (ISSN:18835198)

巻号頁・発行日

vol.12, no.2, pp.53-60, 2020 (Released:2021-02-22)

参考文献数

26

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BackgroundOral dyskinesia is a condition in which oral organs exhibit involuntary movements. The aim of this study was to determine the contribution of oral sensation to the control of oral dyskinesia using an animal model that exhibits vacuous tongue movements after systemic administration of dopamine (DA) agonists.MethodsAdult male Sprague-Dawley rats were used in all experiments. Tongue movement was elicited in a freely moving rat model by systemic administration of a mixture of the D1 receptor agonist SKF38393 and the D2 receptor agonist quinpirole. The number of tongue protrusions was calculated from electrical myographic data obtained from the genioglossal muscle. Extracellular concentrations of DA and serotonin (5-HT) in the nucleus accumbens were determined using in vivo microdialysis. To investigate the effects of oral sensation on vacuous tongue movement, deafferentation of the palatal mucosa was performed, and the above experiments were repeated.ResultsThe hyperactivity of tongue protrusion induced by administration of SKF38393 and quinpirole was significantly inhibited by palatal deafferentation. Palatal deafferentation also significantly reduced the increase in extracellular 5-HT concentration in the nucleus accumbens produced by administration of DA agonists.ConclusionsThese results support the important contribution of oral sensation to vacuous tongue protrusion in a rat model of oral dyskinesia.

著者

Jian Lu Lan Zhang Hironao Okada Toshihiro Itoh Takeshi Harada Ryutaro Maeda

出版者

The Institute of Electrical Engineers of Japan

雑誌

電気学会論文誌E(センサ・マイクロマシン部門誌) (ISSN:13418939)

巻号頁・発行日

vol.135, no.9, pp.355-360, 2015-09-01 (Released:2015-09-01)

参考文献数

14

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System scaling down in the viewpoint of both electrical blocks and physical interconnection is essential to wireless sensor nodes for layout-free and maintenance-free ubiquitous applications in wireless sensor networks (WSN). In this work, a piezoresistive planar MEMS sensor with the sensitivity of 0.2∼0.3 mV/V/g was developed for the monitoring of vibrations at low-frequency of a few Hz. To reduce power consumption of the system to the lowest limit as well as to reduce the quantity of electrical components, a fully-integrated low-power customized LSI with universal interface to sensors was designed and fabricated by using 0.18 µm 1.8V/3.3V 1P6M logic process for power management, data acquisition, data processing, and data transmission by RF signal. Power supply to the sensor can be managed by the customized LSI for reducing its power consumption. Output analog signal from the sensor can be obtained by the customized LSI through on-chip integrated amplifier and AD convertor. To reduce size of the system to the lowest limit, buried bump interconnection technology (B2it™) was introduced for the integration of above customized LSI, MEMS sensor, crystal oscillator, and passive components into a 3D structure. Those technologies enable the production of the world smallest class wireless sensor nodes with ultra-low power consumption for low-frequency vibration monitoring, and for temperature and humidity measurement.