- 著者
- Seiichi Shinji Takeshi Yamada Akihisa Matsuda Hiromichi Sonoda Ryo Ohta Takuma Iwai Koki Takeda Kazuhide Yonaga Yuka Masuda Hiroshi Yoshida
- 出版者
- The Medical Association of Nippon Medical School
- 雑誌
- Journal of Nippon Medical School (ISSN:13454676)
- 巻号頁・発行日
- vol.89, no.3, pp.246-254, 2022-06-25 (Released:2022-06-28)
- 参考文献数
- 80
- 被引用文献数
- 56
Colorectal cancer (CRC) is the third most common cancer worldwide, and surgical treatment remains the first-line treatment to provide a cure. In addition to the aging population, obesity, low physical activity, and smoking habits increase CRC risk. Despite advances in surgical techniques, chemotherapy, and radiotherapy, colorectal cancer remains the second leading cause of cancer-related deaths worldwide. For early-stage CRC, endoscopic treatment, including endoscopic mucosal resection and endoscopic submucosal dissection, has been performed. However, lymph node dissection is an integral part of surgical treatment for advanced-stage cancer because of the high incidence of lymph node metastasis. Conventional open surgery has evolved into laparoscopic and robotic surgery. Although prospective studies have confirmed the safety and feasibility of laparoscopic surgery for CRC, relevant treatment models of transverse colon cancer and rectal cancer still need to be further explored and validated. Furthermore, multidisciplinary treatment is needed to cure CRC completely. This review aimed to provide an update on recent advances in the surgical treatment of CRC.
- 著者
- Yuya Hagiwara Yoshiyuki Yamamoto Yuki Inagaki Reina Tomisaki Miki Tsuji Soma Fukuda Satoshi Fukuda Tsubasa Onoda Hirosumi Suzuki Yusuke Niisato Yoshitaka Tange Naoya Ikeda Keiichi Yamada Mariko Kobayashi Daisuke Akutsu Takeshi Yamada Toshikazu Moriwaki Toshiaki Narasaka Hideo Suzuki Kiichiro Tsuchiya
- 出版者
- The Japanese Society of Internal Medicine
- 雑誌
- Internal Medicine (ISSN:09182918)
- 巻号頁・発行日
- vol.61, no.16, pp.2449-2455, 2022-08-15 (Released:2022-08-15)
- 参考文献数
- 43
- 被引用文献数
- 1
Dihydropyrimidine dehydrogenase (DPD) deficiency induces severe adverse events in patients receiving fluoropyrimidines. We encountered a 64-year-old DPD-deficient man with a severe capecitabine-related gastrointestinal disorder. He received capecitabine-containing chemotherapy after rectal cancer resection. During the first course of chemotherapy, he developed severe diarrhea, a fever, and hematochezia. Endoscopy revealed mucosal shedding with bleeding throughout the gastrointestinal tract. DPD deficiency was suspected because he developed many severe adverse events of capecitabine early and was finally confirmed based on the finding of a low DPD activity level in peripheral blood mononuclear cells. After one month of intensive care, hemostasis and mucosal healing were noted, although his gastrointestinal function did not improve, and he had persistent nutritional management issues.