- 著者
-
Megumi Hara
Yuichiro Nishida
Keitaro Tanaka
Chisato Shimanoe
Kayoko Koga
Takuma Furukawa
Yasuki Higaki
Koichi Shinchi
Hiroaki Ikezaki
Masayuki Murata
Kenji Takeuchi
Takashi Tamura
Asahi Hishida
Mineko Tsukamoto
Yuka Kadomatsu
Keitaro Matsuo
Isao Oze
Haruo Mikami
Miho Kusakabe
Toshiro Takezaki
Rie Ibusuki
Sadao Suzuki
Hiroko Nakagawa-Senda
Daisuke Matsui
Teruhide Koyama
Kiyonori Kuriki
Naoyuki Takashima
Yasuyuki Nakamura
Kokichi Arisawa
Sakurako Katsuura-Kamano
Kenji Wakai
- 出版者
- Japan Epidemiological Association
- 雑誌
- Journal of Epidemiology (ISSN:09175040)
- 巻号頁・発行日
- vol.33, no.6, pp.285-293, 2023-06-05 (Released:2023-06-05)
- 参考文献数
- 49
- 被引用文献数
-
6
Background: Little is known about whether insufficient moderate-to-vigorous physical activity (MVPA) and longer sedentary behavior (SB) are independently associated with estimated glomerular filtration rate (eGFR) and chronic kidney disease (CKD), whether they interact with known risk factors for CKD, and the effect of replacing sedentary time with an equivalent duration of physical activity on kidney function.Methods: We examined the cross-sectional association of MVPA and SB with eGFR and CKD in 66,603 Japanese cohort study in 14 areas from 2004 to 2013. MVPA and SB were estimated using a self-reported questionnaire, and CKD was defined as eGFR <60 mL/min/1.73 m2. Multiple linear regression analyses, logistic regression analyses, and an isotemporal substitution model were applied.Results: After adjusting for potential confounders, higher MVPA and longer SB were independently associated with higher eGFR (P for trend MVPA <0.0001) and lower eGFR (P for trend SB <0.0001), and a lower odds ratio (OR) of CKD (adjusted OR of MVPA ≥20 MET·h/day, 0.76; 95% confidence interval [CI], 0.68–0.85 compared to MVPA <5 MET·h/day) and a higher OR of CKD (adjusted OR of SB ≥16 h/day, 1.81; 95% CI, 1.52–2.15 compared to SB <7 h/day), respectively. The negative association between MVPA and CKD was stronger in men, and significant interactions between sex and MVPA were detected. Replacing 1 hour of SB with 1 hour of physical activity was associated with about 3 to 4% lower OR of CKD.Conclusion: These findings indicate that replacing SB with physical activity may benefit kidney function, especially in men, adding to the possible evidence on CKD prevention.