- 著者
- Tetsuo YAMAMOTO Manabu KINOSHITA Nariyoshi SHINOMIYA Sadayuki HIROI Hidekazu SUGASAWA Yoshitaro MATSUSHITA Takashi MAJIMA Daizoh SAITOH Shuhji SEKI
- 出版者
- Journal of Radiation Research Editorial Committee
- 雑誌
- Journal of Radiation Research (ISSN:04493060)
- 巻号頁・発行日
- vol.51, no.2, pp.145-156, 2010 (Released:2010-03-25)
- 参考文献数
- 38
- 被引用文献数
- 37 28
While bone marrow or stem cell transplantation can rescue bone marrow aplasia in patients accidentally exposed to a lethal radiation dose, radiation-induced irreversible gastrointestinal damage (GI syndrome) is fatal. We investigated the effects of ascorbic acid on radiation-induced GI syndrome in mice. Ascorbic acid (150 mg/kg/day) was orally administered to mice for 3 days, and then the mice underwent whole body irradiation (WBI). Bone marrow transplantation (BMT) 24 h after irradiation rescued mice receiving a WBI dose of less than 12 Gy. No mice receiving 14 Gy-WBI survived, because of radiation-induced GI syndrome, even if they received BMT. However, pretreatment with ascorbic acid significantly suppressed radiation-induced DNA damage in the crypt cells and prevented denudation of intestinal mucosa; therefore, ascorbic acid in combination with BMT rescued mice after 14 Gy-WBI. DNA microarray analysis demonstrated that irradiation up-regulated expressions of apoptosis-related genes in the small intestine, including those related to the caspase-9-mediated intrinsic pathway as well as the caspase-8-mediated extrinsic pathway, and down-regulated expressions of these genes in ascorbic acid-pretreated mice. Thus, pretreatment with ascorbic acid may effectively prevent radiation-induced GI syndrome.
- 著者
- Yoshimasa Funakawa Tsuyoshi Shiozaki Kunikazu Tomita Tetsuo Yamamoto Eiji Maeda
- 出版者
- 一般社団法人 日本鉄鋼協会
- 雑誌
- ISIJ International (ISSN:09151559)
- 巻号頁・発行日
- vol.44, no.11, pp.1945-1951, 2004-11-15 (Released:2007-05-31)
- 参考文献数
- 24
- 被引用文献数
- 132 441
A ferritic steel precipitation-strengthened by nanometer-sized carbides was developed to obtain a high strength hot-rolled sheet steel having tensile strength of 780 MPa grade with excellent stretch flange formability. Manganese in a content of 1.5% and molybdenum in a content of 0.2% were added to 0.04% carbon Ti-bearing steel in order to lower austenite-ferrite transformation temperature for fine carbides and to retard generating of pearlite and large cementites, respectively. Tensile strength of hot-rolled sheet steel increased with titanium content and it was achieved to 800 MPa in a 0.09% Ti steel. Microstructure of the 0.09%Ti steel was ferrite without pearlite and large cementites. Fine carbides of 3 nm in diameter were observed in rows in the ferrite matrix of the 0.09% Ti steel with transmission electron microscope. The characteristic arrangement of the nanometer-sized carbides indicates that the carbides were formed at austenite-ferrite interfaces during transformation. By energy dispersive X-ray spectroscopy, the carbides were found to contain molybdenum in the same atomic concentration as titanium. Crystal structure of the nanometer-sized carbides was determined to be NaCl-type by X-ray diffractometry. The calculated amount of precipitation-strengthening by the carbides was approximately 300 MPa. This is two or three times higher than that of conventional Ti-bearing high strength hot-rolled sheet steels.Based on the results obtained in the laboratory investigation, mill trial was carried out. The developed hot-rolled high strength sheet steel exhibited excellent stretch flange formability.