著者

Chiemi Hotta Yuki Fujinuma Takashi Ogawa Mamiko Akita Tomoko Ogawa

出版者

Japan Epidemiological Association

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

pp.JE20220305, (Released:2023-05-20)

参考文献数

42

被引用文献数

1

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Background: In Japan, sentinel surveillance is used to monitor the trend of infectious gastroenteritis. Another method of pathogen surveillance, wastewater-based epidemiology, has been used recently because it can help to monitor infectious disease without relying on patient data. Here, we aimed to determine the viral trends reflected in the number of reported patients and number of gastroenteritis virus-positive samples. We focused on gastroenteritis viruses present in wastewater and investigated the usefulness of wastewater surveillance for the surveillance of infectious gastroenteritis.Methods: Real-time polymerase chain reaction was used for viral gene detection in wastewater. The number of reported patients per pediatric sentinel site and number of viral genome copies were compared for correlation potential. The number of gastroenteritis virus-positive samples reported by NESID and a status of gastroenteritis viruses detected in wastewater were also evaluated.Results: Genes of norovirus GI, norovirus GII, sapovirus, astrovirus, rotavirus group A, and rotavirus group C were detected in wastewater samples. Viruses were detected in wastewater during periods when no gastroenteritis virus-positive samples were reported to NESID.Conclusions: Norovirus GII and other gastroenteritis viruses were detected in wastewater even during periods when no gastroenteritis virus-positive samples were found. Therefore, surveillance using wastewater can complement sentinel surveillance and is an effective tool for the surveillance of infectious gastroenteritis.

著者

Toshimasa TAKAHASHI Takehiko BABA Tomoko OGAWA Yasuko OKAMOTO Tetsuya TAJIMA Tamaki AGAWA Taro KONDO Kunio YANAI

出版者

Japan Society of Health Evaluation and Promotion

雑誌

総合健診 (ISSN:13470086)

巻号頁・発行日

vol.43, no.4, pp.518-524, 2016 (Released:2016-08-01)

参考文献数

16

被引用文献数

3 3

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Objective. The purpose of the study was to determine the distribution of estimated glomerular filtration rate (eGFR) values among the Japanese working generation using representative health checkup data. Design. Cross-sectional, observational, large cohort study Setting. Japan Health Insurance Association, Tokyo Branch Participants. Data for 766,556 participants aged 35-74 years who attended preventative health checkup for lifestyle-related disease conducted by the Japan Health Insurance Association, Tokyo Branch, in 2012 were included. After excluding dialysis patients and those with missing data, 766,095 participants (mean age, 48.9 years; 68.1% male) were selected for analysis. Main outcome measures. Serum creatinine-based eGFR values were analyzed in 5-year age groups. Results. The age-specific mean eGFR values were 86.4, 83.0, 79.8, 77.4, 75.5, 73.2, 70.9, and 67.8 mL/min/1.73 m2 for the age groups of 35-39, 40-44, 45-49, 50-54, 55-59, 60-64, 65-69, and 70-74 years, respectively. The difference in eGFR per 1-year difference in age was 0.523 mL/min/1.73 m2/year. The mean eGFR was higher in the female participants for all age groups, being most apparent in those aged 35-50 and 60-74 years. However, without body surface-area correction, the mean eGFR was lower in the female participants for all age groups. Conclusion We described the distribution of eGFR values on the basis of a large data set obtained during health checkup examinations in Japan. We found these data to be representative of the 35-74 year-old Japanese general population.