著者

Yasuko Okamoto Takanori Sakaguchi Yoshito Ikematsu Toshikazu Kanai Kazuhisa Hirayama Hiroaki Tamura Tadataka Hayashi Yoshiro Nishiwaki Hiroyuki Konno Katsunori Aoki

出版者

The University of Tokushima Faculty of Medicine

雑誌

The Journal of Medical Investigation (ISSN:13431420)

巻号頁・発行日

vol.70, no.3.4, pp.325-333, 2023 (Released:2023-11-09)

参考文献数

37

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The effects of early enteral arginine-rich nutrition (EAN) were analyzed among patients undergoing curative-intent total gastrectomy for gastric cancer. There were 19 patients in this prospective study, all randomly assigned to either a parenteral nutrition (PN) group or an EAN group for the first seven days after surgery. The EAN group received 1.8-fold greater arginine (10.1 g/day) compared with the PN group, which was administered through an enteral tube inserted into the jejunal loop. Both groups were provided almost identical amounts of total amino acids (54 g/day), and the total energy was set at 65% of the total requirement (25 kcal/kg/day). No significant differences were observed between the two groups in postoperative complications, length of hospital stay, oral intake, nutritional status, or body weight. The serum arginine profile was similar in the two groups, as it decreased significantly on postoperative day (POD) 1, and gradually returned to preoperative levels by POD 7. The nitrogen balance remained negative until POD 7 in the PN group, but turned neutral at POD 7 in the EAN group. While we could not confirm body weight loss improvement, these results suggested that early arginine-rich enteral nutrition could improve the nitrogen balance after total gastrectomy. J. Med. Invest. 70 : 325-333, August, 2023

著者

Toshimasa TAKAHASHI Takehiko BABA Tomoko OGAWA Yasuko OKAMOTO Tetsuya TAJIMA Tamaki AGAWA Taro KONDO Kunio YANAI

出版者

Japan Society of Health Evaluation and Promotion

雑誌

総合健診 (ISSN:13470086)

巻号頁・発行日

vol.43, no.4, pp.518-524, 2016 (Released:2016-08-01)

参考文献数

16

被引用文献数

3 3

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Objective. The purpose of the study was to determine the distribution of estimated glomerular filtration rate (eGFR) values among the Japanese working generation using representative health checkup data. Design. Cross-sectional, observational, large cohort study Setting. Japan Health Insurance Association, Tokyo Branch Participants. Data for 766,556 participants aged 35-74 years who attended preventative health checkup for lifestyle-related disease conducted by the Japan Health Insurance Association, Tokyo Branch, in 2012 were included. After excluding dialysis patients and those with missing data, 766,095 participants (mean age, 48.9 years; 68.1% male) were selected for analysis. Main outcome measures. Serum creatinine-based eGFR values were analyzed in 5-year age groups. Results. The age-specific mean eGFR values were 86.4, 83.0, 79.8, 77.4, 75.5, 73.2, 70.9, and 67.8 mL/min/1.73 m2 for the age groups of 35-39, 40-44, 45-49, 50-54, 55-59, 60-64, 65-69, and 70-74 years, respectively. The difference in eGFR per 1-year difference in age was 0.523 mL/min/1.73 m2/year. The mean eGFR was higher in the female participants for all age groups, being most apparent in those aged 35-50 and 60-74 years. However, without body surface-area correction, the mean eGFR was lower in the female participants for all age groups. Conclusion We described the distribution of eGFR values on the basis of a large data set obtained during health checkup examinations in Japan. We found these data to be representative of the 35-74 year-old Japanese general population.