- 著者
- Hidemasa HIDAKA Toshiaki EIDA Toshio TAKIZAWA Takahisa TOKUNAGA Yasuhito TASHIRO
- 出版者
- Japan Bifidus Foundation
- 雑誌
- Bifidobacteria and Microflora (ISSN:02869306)
- 巻号頁・発行日
- vol.5, no.1, pp.37-50, 1986 (Released:2010-06-28)
- 参考文献数
- 28
- 被引用文献数
- 356 430
A study was made of the effects of fructooligosaccharides, which exist widely inplants such as onion, edible burdock, wheat etc., on the human and animal intestinal flora. Fructooligosaccharides are produced from sucrose with the aid of β-fructofuranosidase from Aspergillus niger on a commercial scale by Meiji Seika Kaisha, Ltd.(Neosugar, Meioligo®). It has been found that they are not hydrolyzed by any digestive enzymes of humans and animals. Moreover utilization byvarious kinds ofintestinal bacteria indicated that Bifidobacterium spp., the Bacteroides fragilis group, Peptostreptococcus spp. and Klebsiella pneumoniae can utilize these saccharides, but Clostridium perfringens, Escherichia coli and others cannot. The fructooligosaccharides are selectively utilized, particularly by bifidobacteria.The clinical studies showed that fructooligosaccharides administration improved the intestinal flora, with subsequent relief of constipation, improved blood lipids in hyperlipidemia, and suppressed the production of intestinal putrefactivesubstances.
- 著者
- Naomi OSAKABE Chiaki SANBONGI Megumi YAMAGISHI Toshio TAKIZAWA Toshihiko OSAWA
- 出版者
- (社)日本農芸化学会
- 雑誌
- Bioscience, Biotechnology, and Biochemistry (ISSN:09168451)
- 巻号頁・発行日
- vol.62, no.8, pp.1535-1538, 1998 (Released:2005-03-25)
- 参考文献数
- 26
- 被引用文献数
- 35
The antiulcer activity of cacao liquor water-soluble crude polyphenols (CWSP) was examined. CWSP, α-tocopherol, sucralfate (500 mg/kg), and cimetidine (250 mg/kg) were orally administerted to male SD rats 30 minutes before ethanol treatment. 5 ml/kg of ethanol given intragastrically caused lesions in mucosa of the glandular stomach. CWSP caused a reduction of such hemorrhagic lesions as well as cimetidine and sucralfate which are typical antiulcer drugs, but α-tocopherol was less effective. Thiobarbituric acid reactive substances in gastric mucosa significantly increased with ethanol administration. CWSP treatment significantly reduced this change. The administration of ethanol extensively increased myeloperoxidase (MPO) but not xanthine oxidase (XOD) activity. CWSP reduced the activities of both enzymes; they were considered the main sources of oxygen radicals. According to an in vitro study, CWSP directly reducted XOD but not MPO. These results suggest that the antiulcer mechanism of CWSP was not only radical scavenging but also modulation of leukocyte function.