- 著者
- Hidemasa HIDAKA Toshiaki EIDA Toshio TAKIZAWA Takahisa TOKUNAGA Yasuhito TASHIRO
- 出版者
- Japan Bifidus Foundation
- 雑誌
- Bifidobacteria and Microflora (ISSN:02869306)
- 巻号頁・発行日
- vol.5, no.1, pp.37-50, 1986 (Released:2010-06-28)
- 参考文献数
- 28
- 被引用文献数
- 356 430
A study was made of the effects of fructooligosaccharides, which exist widely inplants such as onion, edible burdock, wheat etc., on the human and animal intestinal flora. Fructooligosaccharides are produced from sucrose with the aid of β-fructofuranosidase from Aspergillus niger on a commercial scale by Meiji Seika Kaisha, Ltd.(Neosugar, Meioligo®). It has been found that they are not hydrolyzed by any digestive enzymes of humans and animals. Moreover utilization byvarious kinds ofintestinal bacteria indicated that Bifidobacterium spp., the Bacteroides fragilis group, Peptostreptococcus spp. and Klebsiella pneumoniae can utilize these saccharides, but Clostridium perfringens, Escherichia coli and others cannot. The fructooligosaccharides are selectively utilized, particularly by bifidobacteria.The clinical studies showed that fructooligosaccharides administration improved the intestinal flora, with subsequent relief of constipation, improved blood lipids in hyperlipidemia, and suppressed the production of intestinal putrefactivesubstances.
- 著者
- Tsunesuke TOMODA Yasuo NAKANO Takashi KAGEYAMA
- 出版者
- Japan Bifidus Foundation
- 雑誌
- Bifidobacteria and Microflora (ISSN:02869306)
- 巻号頁・発行日
- vol.7, no.2, pp.71-74, 1988 (Released:2010-06-28)
- 参考文献数
- 14
- 被引用文献数
- 13 20
The number of intestinal Candida was correlated with the incidence of Candida infection. The number of intestinal Candida was higher in patients receiving antileukemic chemotherapy than in normal subjects. Respiratory and urinary infections were increased in patients with more than 105 Candida/g feces. Bifidobacterium administered orally to patients with more than 105 Candida/g feces, reduced the incidence of infection if the intestinal Candida population fell to less than 104/g feces.
- 著者
- Ryuichiro TANAKA Hiroo TAKAYAMA Masami MOROTOMI Toshikata KUROSHIMA Sadao UEYAMA Keisuke MATSUMOTO Akio KURODA Masahiko MUTAI
- 出版者
- Japan Bifidus Foundation
- 雑誌
- Bifidobacteria and Microflora (ISSN:02869306)
- 巻号頁・発行日
- vol.2, no.1, pp.17-24, 1983 (Released:2011-02-23)
- 参考文献数
- 25
- 被引用文献数
- 130 184
We studied the effects of administration of TOS, a new growth factor derived from lactose for Bifidobacterium, and Bifidobacterium breve 4006 on the fecal flora of normal subjects. All of the Bifidobacterium species tested, eight reference strains and B. breve 4006 were capable of fermenting TOS in vitro, while others, 2 Bacteroides strains and 4 Lactobacillus and Enterobacteriaceae strains, showed an appreciable growth among 55 cultures tested. It was evident that TOS is not intestinally absorbed by the recipient subjects, from hydrogen breath test. In vivo, TOS (3g or 10g/day) was observed to promote the growth of both administered B. breve 4006 and resident Bifidobacterium strains. Simultaneous administration of B. breve 4006 and TOS caused the suppression of gram negative anaerobes and aerobes, Bacteroidaceae and Enterobacteriaceae, and the reduction of fecal ammonia and urinary indican excretion. It is concluded that TOS is a typical bifidus factor.
- 著者
- Yoshimi BENNO Tomotari MITSUOKA
- 出版者
- Japan Bifidus Foundation
- 雑誌
- Bifidobacteria and Microflora (ISSN:02869306)
- 巻号頁・発行日
- vol.5, no.1, pp.13-25, 1986 (Released:2010-06-28)
- 参考文献数
- 13
- 被引用文献数
- 46 85
The succession of bacterial populations in the large bowel of healthy infants was examined during the first week of life. The predominant fecal organisms by theend of the first week were bifidobacteria, bacteroides, clostridia, enterobacteria, and streptococci. The bacteria isolated from the feces of breast-fed and bottle-fed infants, aged about one month, were identified. The composition of the fecal bacteria varied according to the infant's diet. The organism that showed the highest count and the highest frequency of occurrence in both groups was Bifidobacterium breve. The counts and incidences of Clostridium paraputrificum, C. perfringens, and Bacillus subtilis, the counts of C. clostridiiforme, Bacteroides vulgatus, Veillonella parvula, Lactobacillus gasseri, Escherichia coli, Streptococcus bovis, Enterococcus faecalis, and E. faecium and the incidences of C. difficile, C. tertium, and Pseudomonas aeruginosa in the bottle-fed infants were significantly higher than those in the breast-fed infants. A comparison of the fecal bacteria in healthy adults and aged persons was also made. The numbers of B. distasonis, B. vulgatus, B. adolescentis, and B. longum in the healthy adults were significantly higher than those in the aged persons. A significantly increasednumber of Clostridium paraputrificum was found in the feces of senile subjects. Subsequent studies on development of intestinal microflora in pigs, dogs, rats, and chickens were also described. These dramatic changes in the development of gut colonization were probably brought about by bacterial interactions, as well as changes in food.
- 著者
- Tomoko ARAYA-KOJIMA Tomoko YAESHIMA Norio ISHIBASHI Seiichi SHIMAMURA Hirotoshi HAYASAWA
- 出版者
- Japan Bifidus Foundation
- 雑誌
- Bifidobacteria and Microflora (ISSN:02869306)
- 巻号頁・発行日
- vol.14, no.2, pp.59-66, 1995 (Released:2010-06-28)
- 参考文献数
- 11
- 被引用文献数
- 30 36
The inhibitory effects of human-derived Bifidobacterium longum BB536 on harmful intestinal bacteria were examined by co-cultivation of BB536 with each one of the following eight bacterial strains: Escherichia coli, Klebsiella pneumoniae, Clostridium clostridiiforme, C. perfringens, Bacteroides distasonis, B. fragilis, B. thetaiotaomicron and B. vulgatus. In comparison with the results of mono-cultivation, BB536 inhibited both the growth of these putrefactive bacteria and their production of ammonia, and decreased the pH of the culture medium by producing lactic and acetic acids. Enzy-matic assays showed that in BB536 the sorts of the enzymes involved in ammonia production (urease and amino acid deaminases) were rather few and their activities were weaker than observed in the harmful bacteria, whereas the activities of enzymes involved in ammonia assimilation (glutamine synthetase, glutamate synthase and glutamate dehydrogenase) were much higher in BB536 than in the putrefactive bacteria.