著者

Eri Ohto-Fujita Nozomi Hatakeyama Aya Atomi Shunsuke Yasuda Shoki Kodama Tomoaki Atomi Kazuya Tanaka Noboru Hirose Kenji Harada Yoshihide Asano Toshiyuki Watanabe Yukio Hasebe Miho Shimizu Yoriko Atomi

出版者

The Society of Fiber Science and Technology, Japan

雑誌

Journal of Fiber Science and Technology (ISSN:21897654)

巻号頁・発行日

vol.77, no.10, pp.258-265, 2021 (Released:2021-10-23)

参考文献数

49

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Chicken eggshell membrane (ESM) is a two-layered insoluble sheet located between the eggshell and the albumen and is composed of fibrous proteins. Naturally occurring composite material, such as ESM have various ameliorative effects for osteoarthritis of the knee, joint, and connective tissue when ingested and absorbed as supplements. The physiological effects by oral ESM intake, especially on respiratory function,remain unclear. We have recently reported that tritium-labeled ESM powder can be digested and absorbed by mice and distributed in tissues throughout the body. We have also reported that the application of hydrolyzed water-soluble ESM to human skin significantly improved skin elasticity, which declines with aging, in a before and after comparison at 3 months, and significantly reduced wrinkles at the corners of the eyes compared to controls. In the present double-blind, placebo-controlled study, we examined breathing, skin, and body functions, such as zigzag walking, after ESM ingestion compared to controls. We hypothesized this to improve physical functions by improving the extracellular matrix (ECM) within the range of homeostasis. Among 20 healthy subjects (age: 21–68 years), the group given ESM supplementation for 8 weeks showed significantly increased rate of change in arm skin elasticity, respiratory function (forced expiratory volume in 1 s to forced vital capacity ratio (FEV1/FVC)), and zigzag walking speed compared to controls. There was a significant correlation between the rate of change in FEV1/FVC and that of zigzag walking after 8 weeks compared to the initial values. These functional improvements observed in skin elasticity, lung function, and motor function with oral intake of ESM suggest that maintaining elasticity in the cellular environment can support overall health and activity levels.

著者

Yuhi SAITO Mikio FUJII Toshiyuki WATANABE Kentaro MARUYAMA Yasuyuki KOWATARI Hiromaru OGATA Takehisa KUMAGAI

出版者

BMFH出版会

雑誌

Bioscience of Microbiota, Food and Health (ISSN:21863342)

巻号頁・発行日

vol.36, no.2, pp.55-63, 2017 (Released:2017-04-19)

参考文献数

24

被引用文献数

7

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Lactobacillus paracasei K71 was shown to be effective in alleviating the severity of atopic dermatitis in a randomized controlled trial, and a preliminary open-label trial suggested that strain K71 intake enhanced secretory immunoglobulin A (sIgA) release in the saliva. This study investigated the effect of K71 on sIgA release in a randomized, double-blind, placebo-controlled, parallel-group trial. The trial included 62 Japanese subjects aged 20–64 years with relatively low rates of salivary sIgA release. Subjects (n=31 in each group) were randomly given a tablet containing 100 mg (approximately 2 × 1011 bacteria) of K71 or a placebo tablet daily for 12 weeks. After eliminating data for eight subjects (four in each group) who met the exclusion criteria for efficacy analysis, data for 54 subjects were analyzed. The change in the rate of salivary sIgA release 8 weeks after initiation of the study compared with baseline was significantly higher in the K71 tablet group (105.5 ± 119.0 µg/min) than in the placebo group (52.7 ± 62.6 µg/min; p=0.047). There were no adverse events associated with intake of tablets containing K71. The safety of intake of L. paracasei K71 was also confirmed in an independent open-label trial with 20 healthy subjects who consumed excessive amounts of K71-containing food. L. paracasei K71 intake may therefore have some benefits in promoting mucosal immune function.

著者

Seiichi Tobe Hiroshi Akimoto Hajime Shigematsu Toshiyuki Watanabe Masazumi Kikukawa Hiroshi Miyazawa

出版者

Japan Oil Chemists' Society

雑誌

Journal of Oleo Science (ISSN:13458957)

巻号頁・発行日

vol.57, no.6, pp.353-358, 2008 (Released:2008-05-09)

参考文献数

24

被引用文献数

1 1

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We evaluated the allergen inactivating effect of colloidal silica by performing enzyme-liked immunosorbent assay (ELISA) whose wells were coated with 150 ng/mL of Japanese cedar pollen allergen (Cry j 1) or mite allergen (Der f 2). The allergens were almost 100% inactivated by 100 μg/mL of colloidal silica having a particle size 5 nm, and the inactivating effect was increased by aluminum binding to the surface of the colloidal silica. The results show that colloidal silica is a promising material for allergen inactivation. Since colloidal silica forms an insoluble nondispersive solid when dried, it is expected that airborne allergens can be reduced by binding them to colloidal silica.