- 著者
- Tsubasa SAITO James K. CHAMBERS Ko NAKASHIMA Kazumi NIBE Koichi OHNO Hajime TSUJIMOTO Kazuyuki UCHIDA Hiroyuki NAKAYAMA
- 出版者
- JAPANESE SOCIETY OF VETERINARY SCIENCE
- 雑誌
- Journal of Veterinary Medical Science (ISSN:09167250)
- 巻号頁・発行日
- pp.20-0297, (Released:2020-07-13)
- 被引用文献数
- 6
Wnt/beta-catenin signaling, E-cadherin and p53 reportedly play important roles in the development and/or progression of human gastrointestinal cancer. The present study evaluated the roles of beta-catenin, E-cadherin and p53 in canine gastrointestinal tumors. Endoscopic biopsy or surgically resected samples, a total of 131, including 38 gastric, 13 small intestinal and 80 large intestinal tumors, were obtained from 95 dogs. Those specimens were examined pathologically. Immunohistochemically, nuclear beta-catenin expression was found in 88% (42/48) of polypoid type adenocarcinomas. Most cases of non-polypoid type adenocarcinomas lacked nuclear expression of beta-catenin with the exception of one case (6%, 1/17). Nuclear beta-catenin expression was not observed in signet ring cell carcinomas (0/15), mucinous adenocarcinomas (0/7) and undifferentiated carcinomas (0/4). The findings indicate that nuclear translocation of beta-catenin is closely related to the development of polypoid type adenocarcinomas but not that of non-polypoid type malignant tumors. The immunoreactivity of E-cadherin for tumor cells tended to decline overall in most of cases including benign tumors. Significant immunoreactivity for p53 was not found in 61% of tumors examined (80/131), including malignant tumors (63%, 57/91), while intense p53-immunoreactivity was rarely found in a few cases of malignant tumors (8%, 7/91). We could not conclude clearly significant correlations between histopathological tumor types and immunohistochemical results of E-cadherin or p53. This paper indicates the importance of the nuclear translocation of beta-catenin for the tumorigenesis of canine intestinal polypoid type adenocarcinomas, especially in the colorectum.
- 著者
- Makoto NAKATA Yasutsugu MIWA James K. CHAMBERS Tsubasa SAITO Kazuyuki UCHIDA
- 出版者
- JAPANESE SOCIETY OF VETERINARY SCIENCE
- 雑誌
- Journal of Veterinary Medical Science (ISSN:09167250)
- 巻号頁・発行日
- vol.80, no.8, pp.1325-1328, 2018 (Released:2018-08-30)
- 参考文献数
- 17
- 被引用文献数
- 6
A 14-month-old, female mini rex was referred for a detailed examination because of exercise intolerance with associated dyspnea. The thoracic radiograph demonstrated severe cardiac enlargement and elevation of the trachea. The echocardiography revealed dilatations of the right-side heart and pulmonary artery, and the color flow Doppler echocardiography demonstrated an atrial septum defect with left to right shunt, resulting in a disturbed flow. The rabbit died 19 days after the initial presentation, and a necropsy was performed. At the necropsy, a defect, 5 mm in diameter, was detected in the atrial septum. Based on the location of the defect, an ostium secundum type atrial septal defect was diagnosed. This is the first clinical report of atrial septal defect in rabbits.
- 著者
- Satoko Kikkawa Tsubasa Saito Emiko Ishiwata Hidehiko Hasegawa
- 出版者
- 一般社団法人 日本応用数理学会
- 雑誌
- JSIAM Letters (ISSN:18830609)
- 巻号頁・発行日
- vol.5, pp.9-12, 2013 (Released:2013-02-24)
- 参考文献数
- 6
- 被引用文献数
- 2
MuPAT enables the users to easily treat quadruple and octuple precision arithmetics as well as double precision arithmetic on Scilab. Using external C routines, we have also developed a high speed implementation MuPAT_c for Windows, Mac OS, and Linux. MuPAT_c reduced the computation time especially for all octuple precision arithmetic and inner product of quadruple precision arithmetic. MuPAT_c can run 90-1200 times faster than MuPAT. We applied three different precisions to tridiagonalization by the Lanczos method and confirmed that a high precision arithmetic was essential for the Lanczos method to get accurate eigenvalues of real symmetric matrices.