- 著者
- Anthony C. Keech Kazuma Oyama Peter S. Sever Minao Tang Sabina A. Murphy Atsushi Hirayama Chen Lu Leslie Tay Prakash C. Deedwania Chung-Wah Siu Armando Lira Pineda Donghoon Choi Min-Ji Charng John Amerena Wan Azman Wan Ahmad Vijay K. Chopra Terje R. Pedersen Robert P. Giugliano Marc S. Sabatine on behalf of the FOURIER Study Group
- 出版者
- The Japanese Circulation Society
- 雑誌
- Circulation Journal (ISSN:13469843)
- 巻号頁・発行日
- pp.CJ-20-1051, (Released:2021-05-12)
- 参考文献数
- 19
- 被引用文献数
- 13
Background:There are concerns that Asian patients respond differently to some medications. This study evaluated the efficacy and safety of evolocumab among Asian vs. other subjects in the FOURIER trial, which randomized stable atherosclerosis patients to receive either evolocumab or placebo.Methods and Results:Effects of adding evolocumab vs. placebo to background statin therapy on low-density lipoprotein cholesterol (LDL-C) reductions, cardiovascular outcomes, and adverse events were compared among 27,564 participants with atherosclerotic disease, according to self-reported Asian (n=2,723) vs. other (n=24,841) races followed for a median of 2.2 years in the FOURIER trial. The primary endpoint was a composite of cardiovascular death, myocardial infarction, stroke, hospitalization for unstable angina, or coronary revascularization. At randomization, Asians had slightly lower LDL-C (median 89 [IQR 78–104] mg/dL vs. 92 [80–109] mg/dL; P<0.001) and were much less likely to be on a high-intensity statin (33.3% vs. 73.3%; P<0.001). Evolocumab lowered LDL-C more in Asians than in others (66% vs. 58%; P<0.001). The effect of evolocumab on the primary endpoint was similar in Asians (HR, 0.79; 95% CI, 0.61–1.03) and others (HR, 0.86; 95% CI, 0.79–0.93; P interaction=0.55). There was no excess of serious adverse events with evolocumab among Asians over others.Conclusions:Use of evolocumab robustly lowers LDL-C and is equally efficacious in lowering the risk of cardiovascular events and safe in Asians as it is in others.
- 著者
- Hazem Doufesh Fatimah Ibrahim Noor Azina Ismail Wan Azman Wan Ahmad
- 出版者
- The Society of Physical Therapy Science
- 雑誌
- Journal of Physical Therapy Science (ISSN:09155287)
- 巻号頁・発行日
- vol.25, no.2, pp.211-214, 2013 (Released:2013-03-22)
- 参考文献数
- 39
- 被引用文献数
- 2 7
[Purpose] This study reports the effects of the Muslim prayer, known as Salat, on heart rate (HR) and blood pressure (BP) while performing and miming the actions of Salat: standing, bowing, prostrating and sitting. [Subjects] Thirty Muslim subjects were asked to perform the actual and mime Salat. [Methods] HR and BP were measured using a Schiller AT-102 Electrocardiograph and an Omron SEM-1 Automatic Blood Pressure Monitor. [Results] The findings revealed that there was a significant difference in the HR of the subjects between performing and miming Salat. The standing and prostration positions of Salat produced the highest and the lowest HR, respectively. A lower HR may be of potential benefit to an individual’s health. The systolic and the diastolic BP decreased significantly after performance and mime of Salat, and a greater reduction in BP was observed during performance of Salat. [Conclusion] This is the first study of HR and BP in relation to Salat positions. The findings will encourage further studies to explore the benefits of Salat maneuvers for patients with cardiovascular diseases.