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2 0 0 0 OA Anticoagulant and fibrinolytic effects of functional food materials produced by Bacillus subtilis natto

著者
Masahito Hitosugi Masashi Ikeda Xia Zhu Hisayoshi Kato Kazunobu Omura Toshiaki Nagai Shogo Tokudome
出版者
Japanese Society of Biorheology
雑誌
日本バイオレオロジー学会誌 (ISSN:09134778)
巻号頁・発行日
vol.21, no.1, pp.35-40, 2007-03-25 (Released:2012-09-24)
参考文献数
12
We compared the anticoagulant and fibrinolytic effects of the major functional food products generated by Bacillus subtilis natto. We analyzed NSK-SDR and NKCPR powders that consist mainly of nattokinase and bacillopeptidase F, respectively. The specific activity of the plasmin-like activity of NKCPR H was about 2.5-fold higher than that of NSK-SDR. Although both NSK-SDR and NKCPR reduced fibrin monomer levels in human blood, the anticoagulant effect of NKCPR was over 100-fold higher than that of NSK-SDR. Dietary supplements with anticoagulant and fibrinolytic effects might play an important role in preventing thrombotic diseases.

1 0 0 0 OA Modified rice bran hemicellulose inhibits vascular endothelial growth factor-induced angiogenesis in vitro via VEGFR2 and its downstream signaling pathways

著者
Xia ZHU Aya OKUBO Naoki IGARI Kentaro NINOMIYA Yukari EGASHIRA
出版者
BMFH出版会
雑誌
Bioscience of Microbiota, Food and Health (ISSN:21863342)
巻号頁・発行日
vol.36, no.2, pp.45-53, 2017 (Released:2017-04-19)
参考文献数
46
被引用文献数
8
Angiogenesis is implicated in diverse pathological conditions such as cancer, rheumatoid arthritis, psoriasis, atherosclerosis, and retinal neovascularization. In the present study, we investigated the effects of modified rice bran hemicellulose (MRBH), a water-soluble hemicellulose preparation from rice bran treated with shiitake enzymes, on vascular endothelial growth factor (VEGF)-induced angiogenesis in vitro and its mechanism. We found that MRBH significantly inhibited VEGF-induced tube formation in human umbilical vein endothelial cells (HUVECs) co-cultured with human dermal fibroblasts. We also observed that MRBH dose-dependently suppressed the VEGF-induced proliferation and migration of HUVECs. Furthermore, examination of the anti-angiogenic mechanism indicated that MRBH reduced not only VEGF-induced activation of VEGF receptor 2 but also of the downstream signaling proteins Akt, extracellular signal-regulated protein kinase 1/2, and p38 mitogen-activated protein kinase. These findings suggest that MRBH has in vitro anti-angiogenic effects that are partially mediated through the inhibition of VEGF signaling.