著者
Wei WANG Shaozhong LUO Yaping CHEN Bo LI Masao HATTORI
出版者
(社)日本分析化学会
雑誌
Analytical Sciences (ISSN:09106340)
巻号頁・発行日
vol.32, no.6, pp.705-707, 2016-06-10 (Released:2016-06-10)
参考文献数
15
被引用文献数
7

An effective separation and simultaneous determination of corynoxeine and its metabolites using high-performance liquid chromatography with tandem mass spectrometry was developed and validated. The method was applied to pharmacokinetics and in vivo distribution investigations in rats after oral (0.105 mmol kg−1) and intravenous (0.0105 mmol kg−1) doses of corynoxeine. Its brain uptake index was of 3.08 × 10−11 mol g−1 at 3 h and 3.75 × 10−11 mol g−1 at 74 min after oral and intravenous doses, respectively.