著者

Yi Sun Jialai Zhu Norio Mori

出版者

Japan Brain Science society

雑誌

脳科学誌 (ISSN:13415301)

巻号頁・発行日

vol.43, pp.50-57, 2014-05-30 (Released:2017-06-01)

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In recent years, small animal PET-CT, as a biomedical research technology, is widely used on the animal model research. High-resolution animal PET scanner has been developed that can provide accurate rates of cerebral glucose metabolism in conscious rats. This paper mainly discusses brain metabolic changes induced by radiation injury in according to glucose metabolism study in brain and the development of small animal PET

著者

Shen Chen Yi Sun

出版者

Japan Brain Science society

雑誌

脳科学誌 (ISSN:13415301)

巻号頁・発行日

vol.41, pp.48-54, 2013-09-30 (Released:2017-06-01)

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In recent years, hematopoietic stem cells to repair damage well, especially in the CD34 positive cells as the representative of the hematopoietic cell become a research hotspot, but the CD34 positive cells in the body content low, how to get a large number of CD34 positive cells become one of the difficulties of CD34 positive cells. This article reviews the methods commonly used to collect CD34 isthmic cells now, convenient for researchers to find a suitable or find new research methods.

著者

Chaoxin Fan Fang Tian Xin Zhao Yi Sun Xiaogai Yang Hongbin Han Xiaoping Pu

出版者

The Pharmaceutical Society of Japan

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.43, no.9, pp.1306-1314, 2020-09-01 (Released:2020-09-01)

参考文献数

22

被引用文献数

1 6

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The extracellular space (ECS) is the space between the neurons and the capillaries in the brain. The volume fraction (α) and the tortuosity (λ) are the main parameters used to describe its characteristics. Thymoquinone has been proved to possess anti-oxidant and anti-inflammatory activity. In this study, we used a gadolinium-diethylenetriaminepentacetate (Gd-DTPA)-enhanced magnetic resonance imaging (MRI) system to determine the effects of thymoquinone on ECS parameters in transient middle cerebral artery occlusion rats (tMCAO) to prove the neuroprotective effect of thymoquinone on brain tissue damage caused by ischemic stroke. Neurological examinations, 2,3,5-triphenyltetrazolium chloride (TTC) staining, hematoxylin–eosin (H&E) staining and assaying of ECS parameters using MRI were performed 24 h after surgery. We found that thymoquinone could improve the behavioural performance by neurological examinations. TTC staining indicated that thymoquinone significantly decreased the percentage of hemi-cerebral infarction. Also, H&E staining showed that thymoquinone could inhibit the neuron necrosis in the hippocampal CA1 region. We found that thymoquinone treatment could inhibit the changes in ECS diffusion parameters, which might prove that thymoquinone might protect brain tissue damage caused by ischemic stroke. Thymoquinone can protect the brain against cerebral ischemia–reperfusion injury, effectively ameliorate abnormalities in characteristics of ECS and decrease cerebral infarction in tMCAO rats.