- 著者
- Yuko CHIBA Katsuhiko SATOH Satoshi UEDA Nobuo KANAZAWA Yoshiaki TAMURA Toshiyuki HORIUCHI
- 出版者
- The Japan Endocrine Society
- 雑誌
- Endocrine Journal (ISSN:09188959)
- 巻号頁・発行日
- vol.54, no.3, pp.379-383, 2007 (Released:2007-07-19)
- 参考文献数
- 21
- 被引用文献数
- 14 26
Psychosomatic symptoms in primary hyperparathyroidism (PHPT) are various and include such conditions as obsessive-compulsive disorder, depression, anxiety, and paranoia. In the elderly the clinical features of the disease are often non-specific and difficult to diagnose. To quantify subjective symptoms of patients with hyperparathyroidism in the elderly, we determined whether these clinical manifestations resolved after surgical parathyroidectomy (PTX) in three PHPT patients over eighty years old. They were diagnosed with hypercalcemia, hypophosphatemia, high PTH concentrations, and osteoporosis. A single parathyroid adenoma was confirmed in each patient by Tc-MIBI scintigram, neck ultrasonography and computed tomographic scanning. PTX was performed in these three patients. Assessments of psychologic symptoms, using the Hamilton Rating Scale for Depression (HAM-D), serum calcium, and intact PTH were obtained before and after PTX. Mean weight of the resected adenomas was 438 ± 138 mg (mean ± SD). After PTX, serum calcium decreased from 11.1 ± 0.5 to 9.2 ± 0.5 mg/dl and intact PTH from 160.0 ± 25.2 to 45.3 ± 22.2 pg/ml. Total HAM-D scores in each patient decreased from 45 to 9, 17 to 1 and 15 to 5, respectively. Especially, there were marked improvements in depressive mood, psychomotor inhibition, anxiety and somatic symptoms after PTX. The quality of life in those patients was also improved by PTX. We propose here that PTX in elderly PHPT patients with psychiatric symptoms should be considered instead of oral administration, such as anti-depressants or bisphosphonates.
- 著者
- Ichiro Kawasaki Yasuhiro Asai Yoshiaki Tamura Takeshi Sagiya Naoya Mikami Yoshimitsu Okada Masaharu Sakata Minoru Kasahara
- 出版者
- The Seismological Society of Japan, The Volcanological Society of Japan, The Geodetic Society of Japan
- 雑誌
- Journal of Physics of the Earth (ISSN:00223743)
- 巻号頁・発行日
- vol.43, no.2, pp.105-116, 1995 (Released:2009-04-30)
- 参考文献数
- 22
- 被引用文献数
- 78 98
We report the detection of a large ultra-slow earthquake. Subsequent to the July 18, 1992, Sanriku-Oki, Japan, earthquake (Ms6.9, 39.42°N, 143.33°E), a clear post-seismic phase appeared in the crustal strains recorded by quartz-tube extensometers at Esashi (Δ=174 km, φ = -99°, from the NEIC CMT source). We have decomposed the crustal strains into atmospheric pressure effects, tides and trends by the Bayesian tidal analysis method. The EW component of the trend thus extracted displays a clear quasi-static increase of -4 x 10-8 with a time constant of about one day. This is about four times greater than the co-seismic strain step. We have investigated the cause of the post-seismic phase to conclude that this was not due to local disturbances. A similar post-seismic phase of -15 x 10-8 was also observed in the EW component of crustal strain records at Miyako (Δ =117 km, φ = - 80° ), Tohoku University. From the close similarity between the post-seismic waveforms at Esashi and Miyako, we attribute the post-seismic phase to the ultra-slow faulting subsequent to the seismic event. We have inverted the strain steps to obtain a solution of an interplate low-angle thrusting located about 54 km to the east from the NEIC CMT epicenter with a moment release of up to (1-4) x 1020 m, which corresponds to that of a MW7.3-7.7 seismic event.