著者

湯沢 純子 渡邊 佳明 松永 しのぶ Junko YUZAWA Yoshiaki WATANABE Shinobu MATSUNAGA

雑誌

昭和女子大学生活心理研究所紀要 = Annual bulletin of Institute of Psychological Studies, Showa Women's University (ISSN:18800548)

巻号頁・発行日

vol.10, pp.119-129, 2008-03-31

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Objective: The purpose of this study was to examine the feelings of mothers caring for children with autism. In addition, mother's stress and support needs were investigated. Methods: 88 mothers of individuals with autism completed questionnaires on the feelings of mothers with handicapped children, social support, and they freely described the mother's stress and support needs. Results: Factor analysis revealed that mother's feelings consisted of four factors: Pessimistic Feelings, Positive Attitudes to Childcare, Self-Growth, and Inability to Accept Disability. Compared to mothers of children with autism with severe intellectual disabilities, those of children without intellectual disabilities had a significantly greater Inability to Accept Disability. Many mothers experienced the most stress during infancy, and stressors included the challenging behaviors of the child and the difficulty of childcare. Effective sources of support included other parents of children with autism, professionals, and the husband. Conclusion: Positive and negative feelings of mothers of children with autism were identified. Mothers experienced various types of stressors, and these stressors continued beyond adulthood. Finally, the clinical implications of the present results are discussed.

著者

Takuya Shiraishi Shojiro Kadono Masayuki Haramura Hirofumi Kodama Yoshiyuki Ono Hitoshi Iikura Tohru Esaki Takaki Koga Kunihiro Hattori Yoshiaki Watanabe Akihisa Sakamoto Kazutaka Yoshihashi Takehisa Kitazawa Keiko Esaki Masateru Ohta Haruhiko Sato Toshiro Kozono

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.58, no.1, pp.38-44, 2010-01-01 (Released:2010-01-01)

参考文献数

29

被引用文献数

1

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Selective factor VIIa-tissue factor complex (FVIIa/TF) inhibition is regarded as a promising target for developing new anticoagulant drugs. In previous reports, we described a S3 subsite found in the X-ray crystal structure of compound 2 that bound to FVIIa/soluble tissue factor (sTF). Based on the X-ray crystal structure information and with the aim of improving the inhibition activity for FVIIa/TF and selectivity against other serine proteases, we synthesized derivatives by introducing substituents at position 5 of the indole ring of compound 2. Among them, compound 16 showed high selectivity against other serine proteases. Contrary to our expectations, compound 16 did not occupy the S3-subsite; X-ray structure analysis revealed that compound 16 improved selectivity by forming hydrogen bonds with Gln217, Thr99 and Asn100.