- 著者
- Haruhiko SATO
- 出版者
- Japanese Society of Physical Therapy
- 雑誌
- Physical Therapy Research (ISSN:21898448)
- 巻号頁・発行日
- vol.23, no.1, pp.8-14, 2020-06-20 (Released:2020-06-20)
- 参考文献数
- 72
- 被引用文献数
- 12
Despite the fact that children with cerebral palsy may not have any deformities at the time of birth, postural deformities, such as scoliosis, pelvic obliquity, and windswept hip deformity, can appear with increasing age. This may lead to respiratory function deterioration and, in more severe cases, affects survival. To date, postural care is believed to help improve the health and quality of life of children with cerebral palsy. This review provides an overview of the cause and clinical management of postural deformity that is seen in children with cerebral palsy.
- 著者
- Kazutaka Tachibana Ikuhiro Imaoka Takuya Shiraishi Hitoshi Yoshino Mitsuaki Nakamura Masateru Ohta Hiromitsu Kawata Kenji Taniguchi Nobuyuki Ishikura Toshiaki Tsunenari Hidemi Saito Masahiro Nagamuta Toshito Nakagawa Kenji Takanashi Etsuro Onuma Haruhiko Sato
- 出版者
- The Pharmaceutical Society of Japan
- 雑誌
- Chemical and Pharmaceutical Bulletin (ISSN:00092363)
- 巻号頁・発行日
- vol.57, no.10, pp.1178, 2009-10-01 (Released:2009-10-03)
- 著者
- Takuya Shiraishi Shojiro Kadono Masayuki Haramura Hirofumi Kodama Yoshiyuki Ono Hitoshi Iikura Tohru Esaki Takaki Koga Kunihiro Hattori Yoshiaki Watanabe Akihisa Sakamoto Kazutaka Yoshihashi Takehisa Kitazawa Keiko Esaki Masateru Ohta Haruhiko Sato Toshiro Kozono
- 出版者
- The Pharmaceutical Society of Japan
- 雑誌
- Chemical and Pharmaceutical Bulletin (ISSN:00092363)
- 巻号頁・発行日
- vol.58, no.1, pp.38-44, 2010-01-01 (Released:2010-01-01)
- 参考文献数
- 29
- 被引用文献数
- 1
Selective factor VIIa-tissue factor complex (FVIIa/TF) inhibition is regarded as a promising target for developing new anticoagulant drugs. In previous reports, we described a S3 subsite found in the X-ray crystal structure of compound 2 that bound to FVIIa/soluble tissue factor (sTF). Based on the X-ray crystal structure information and with the aim of improving the inhibition activity for FVIIa/TF and selectivity against other serine proteases, we synthesized derivatives by introducing substituents at position 5 of the indole ring of compound 2. Among them, compound 16 showed high selectivity against other serine proteases. Contrary to our expectations, compound 16 did not occupy the S3-subsite; X-ray structure analysis revealed that compound 16 improved selectivity by forming hydrogen bonds with Gln217, Thr99 and Asn100.
- 著者
- Kazutaka Tachibana Ikuhiro Imaoka Takuya Shiraishi Hitoshi Yoshino Mitsuaki Nakamura Masateru Ohta Hiromitsu Kawata Kenji Taniguchi Nobuyuki Ishikura Toshiaki Tsunenari Hidemi Saito Masahiro Nagamuta Toshito Nakagawa Kenji Takanashi Etsuro Onuma Haruhiko Sato
- 出版者
- The Pharmaceutical Society of Japan
- 雑誌
- Chemical and Pharmaceutical Bulletin (ISSN:00092363)
- 巻号頁・発行日
- vol.56, no.11, pp.1555-1561, 2008-11-01 (Released:2008-11-01)
- 参考文献数
- 21
- 被引用文献数
- 14 19
The 3-(4-cyano-3-trifluoromethylphenyl)-5,5-dimethylthiohydantoin derivatives which have carboxy-terminal side chains were synthesized and their agonistic/antagonistic activities against androgen receptor (AR) measured. Among them, compound 13b showed antagonistic activity (IC50=130 nM) with no agonistic activity even at 10000 nM. This compound exhibited significant metabolic stability and oral antiandrogenic activity (ED50=7 mg/kg).
- 著者
- Kosuke Mizuno Yoshitaka Shiba Haruhiko Sato Naoto Kamide Michinari Fukuda Noriaki Ikeda
- 出版者
- The Society of Physical Therapy Science
- 雑誌
- Journal of Physical Therapy Science (ISSN:09155287)
- 巻号頁・発行日
- vol.25, no.1, pp.97-100, 2013 (Released:2013-02-25)
- 参考文献数
- 24
- 被引用文献数
- 1 3
[Purpose] The purpose of this study was to investigate the reliability and validity of the kinematic analysis of trunk and pelvis movement during gait and standing as measured by two smartphones (in the present study, we used iPod touches because of their weight). [Methods] Thirty-eight healthy adults (mean age, 21.4 ± 1.2 years) were instructed to stand and walk on a treadmill at three different speeds. The tilt angle of the trunk and pelvis were measured using both an iPod touch and an optoelectronic motion capture system (Optotrak). [Results] The error between the iPod touch and Optotrak was small during standing and walking at low speed. However, as the walking speed was increased, the error between the iPod touch and Optotrak increased. There were no significant differences between the test and retest measurement values of each device, nor were there any significant differences between the days of the analyses. [Conclusions] The iPod touch has good accuracy, since the variations in the test and retest and for different days were small. This suggests that the iPod touch can be used instead of the Optotrak for the kinematic analysis of trunk and pelvis movement at low walking speeds.