著者

小林 美和 コバヤシ ヨシカズ Yoshikazu Kobayashi

雑誌

帝塚山大学現代生活学部紀要 = Journal of contemporary human life science,Tezukayama University

巻号頁・発行日

vol.1, pp.39-48, 2005-02-01

著者

小林 美和 冨安 郁子 コバヤシ ヨシカズ トミヤス イクコ Yoshikazu Kobayashi Ikuko Tomiyasu

雑誌

帝塚山大学現代生活学部紀要 = Journal of contemporary human life science,Tezukayama University

巻号頁・発行日

vol.3, pp.11-24, 2007-02

著者

Taro Okui Yoshikazu Kobayashi Madoka Isomura Masakazu Tsujimoto Koji Satoh Hiroshi Toyama

出版者

Fujita Medical Society

雑誌

Fujita Medical Journal (ISSN:21897247)

巻号頁・発行日

pp.2022-025, (Released:2022-12-27)

参考文献数

30

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Objectives: This study investigated the relationships between quantitative values calculated from bone single photon emission computed tomography/computed tomography (SPECT/CT) images and histopathological findings observed in surgical specimens from patients with antiresorptive agent-related osteonecrosis of the jaw (ARONJ); it sought to clarify histopathological factors that cause accumulation in bone SPECT/CT images of patients with ARONJ.Methods: This study included 81 pathological specimens of 21 lesions obtained from 18 patients with ARONJ who underwent SPECT/CT and jaw resection. The maximum standardized uptake value (SUVmax) of each volume of interest of the specimens was calculated using RAVAT® software. The ratio of the SUVmax to the mean value of SUVmax in temporal bone was termed rSUVmax. The rSUVmax and pathological findings (sequestration, degree of fibrosis, degree of trabecular bone destruction, degree of inflammatory cell infiltration, and vascularity) were compared using the Mann–Whitney U test and the Kruskal–Wallis test.Results: In univariate analysis with rSUVmax as the dependent variable, the pathological findings of sequestration (P=0.058), degree of fibrosis (P=0.810), degree of trabecular bone destruction (P=0.237), degree of inflammatory cell infiltration (P=0.120), and vascularity (P=0.111) showed no significant difference among the groups for each variable.Conclusions: We found no association between quantitative values in bone SPECT/CT and histological changes in ARONJ, probably because bone SPECT/CT has limited spatial resolution. Limitations of this study may include the imaging findings of a decrease in tracer accumulation because of an involucrum of necrosed bone, various histopathological findings in ARONJ, and failure to consider the effect of preoperative anti-inflammatory treatment.

著者

小林 美和 コバヤシ ヨシカズ Yoshikazu Kobayashi

雑誌

帝塚山短期大学紀要. 人文・社会科学編・自然科学編

巻号頁・発行日

vol.32, pp.1-10, 1995-02-01

著者

小林 美和 コバヤシ ヨシカズ Yoshikazu Kobayashi

雑誌

帝塚山短期大学紀要. 人文・社会科学編・自然科学編

巻号頁・発行日

no.32, pp.1-10, 1995-02-01