- 著者
-
Namiko IKEDA
Daiki KATO
Masaya TSUBOI
Ryohei YOSHITAKE
Shotaro ETO
Sho YOSHIMOTO
Masahiro SHINADA
Satoshi KAMOTO
Yuko HASHIMOTO
Yousuke TAKAHASHI
James CHAMBERS
Kazuyuki UCHIDA
Ryohei NISHIMURA
Takayuki NAKAGAWA
- 出版者
- JAPANESE SOCIETY OF VETERINARY SCIENCE
- 雑誌
- Journal of Veterinary Medical Science (ISSN:09167250)
- 巻号頁・発行日
- vol.83, no.12, pp.1885-1890, 2021 (Released:2021-12-02)
- 参考文献数
- 27
- 被引用文献数
-
1
Cancer immunotherapy is a novel cancer treatment for canine tumors. Indoleamine 2,3-dioxygenase 1 (IDO1) is overexpressed in some human tumors and inhibits antitumor immunity. In this study, we comprehensively evaluated expression pattern of IDO1 and the nature of IDO1-expressing cells in canine normal and tumor tissues. In normal tissue samples, IDO1 expression was detected only in the lymph nodes, spleen, tonsil tissues, and colon tissues. In contrast, IDO1-positive tumor cells were observed in several tumor tissue types. This is the first study to evaluate IDO1 expression in canine normal and tumor tissues, and the results suggest that IDO1 is a promising target for novel cancer immunotherapy in dogs with tumors.